文献类型：期刊文献

中文题名：中医药抗肝纤维化作用机制概述

英文题名：Mechanism of Anti Hepatic Fibrosis of Traditional Chinese Medicine

作者：汪龙德[1];吴红莉[2];吴溪玮[2];刘俊宏[1];张晶[2];毛兰芳[1];杜晓娟[1];任培培[2];杨博[2]

第一作者：汪龙德

机构：[1]甘肃中医药大学附属医院,甘肃兰州730000;[2]甘肃中医药大学,甘肃兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2019

卷号：31

期号：5

起止页码：818

中文期刊名：中医药临床杂志

外文期刊名：Clinical Journal of Traditional Chinese Medicine

基金：甘肃省中医药管理局项目(GZK-2016-19);甘肃省自然科学基金项目(310RJZA102);甘肃省科技局项目(2018-3-42);敦煌医学与转化教育部重点实验室开放基金项目(DHYX18-27)

语种：中文

中文关键词：中药;肝纤维化;机制

外文关键词：Traditional Chinese medicine;Liver fibrosis;Mechanism

摘要：肝纤维化是由于多种原因导致的肝细胞外基质异常沉积的病理状态,因此,及时逆转肝纤维化是治疗疾病的关键。相关研究结果表明,白藜芦、苦参、白芍、丹参等单味中药及中药复方具有明显抗肝纤维化效果,其机制主要是抑制肝星状细胞活性、减少细胞外基质沉积及调节相关信号通路等。
liver fibrosis is the pathological state of abnormal deposition of the extracellular matrix of the liver because of many reasons. Therefore, it is the key to cure the disease by reversing the liver fibrosis in time. The related research results show that the single flavored Chinese medicine and Chinese herbal compound, such as resveratrol,Sophora flavescens and Radix Paeoniae Paeoniae, have obvious effect on liver fibrosis. The main mechanism is to inhibit the activity of hepatic stellate cells, reduce the deposition of extracellular matrix and regulate the related signal pathways.