文献类型：期刊文献

中文题名：基于中医“阴虚”理论探讨水通道蛋白在干燥综合征发病机制的研究现状

英文题名：Research status of aquaporins in the pathogenesis of Sj?gren's syndrome based on the traditional Chinese medicine theory of"Yin deficiency"

作者：张国华[1];张瑞耀[1];汪湛东[1];白敏[1];宋冰[2];张延英[2];汪永锋[2]

第一作者：张国华

机构：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000;[2]甘肃省实验动物行业技术中心,甘肃兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2025

卷号：41

期号：6

起止页码：890

中文期刊名：中国临床药理学杂志

外文期刊名：The Chinese Journal of Clinical Pharmacology

收录：;北大核心:【北大核心2023】；

基金：甘肃省自然科学基金资助项目(23JRRA1227);甘肃省优秀博士生基金资助项目(22JR5RA573)。

语种：中文

中文关键词：中医;“阴虚”理论;干燥综合征;水通道蛋白;病理机制

外文关键词：traditional Chinese medicine;"Yin deficiency"theory;Sjogren's syndrome;aquaporins;pathogenesis

摘要：干燥综合征(SS)是一种慢性自身免疫性疾病,除了影响泪腺和唾液腺,导致眼睛干涩和口干症状外,还会累及人体心、肺、肾和中枢神经等多个系统。目前,水通道蛋白(AQPs)的发现对本病的病理演变及治疗带来了很大的前景。中医药在整体观的基础上,能够辨证施治,随证遣方加减用药,具有多靶点、多层次、多途径的特点,在治疗本病方面有着较大的优势。“阴虚”理论是中医学重要的病理机制理论,目前被众多医家用来解释SS的病因病机。中医“阴虚”理论可为SS的发病机制提供新的视角,并为该病的中西医结合治疗策略提供理论支持。
Sj?gren's syndrome(SS)is a chronic autoimmune disease that affects the lacrimal and salivary glands,leading to symptoms of dry eyes and dry mouth,in addition to a number of systems in the human body,including the heart,lungs,kidneys,and central nervous system.The current discovery of aquaporins(AQPs)holds great promise for the pathological evolution and treatment of this disease.Based on the holistic view,Chinese medicine is able to discriminate and treat the disease with prescription and medication,which has the characteristics of multi-targets,multi-levels,and multi-pathways,and has great advantages in the treatment of this disease.The theory of"Yin deficiency"is an important theory of Chinese medicine,and is currently used by many physicians to explain the etiology of SS.In this paper,the role of AQPs in the pathogenesis of SS is investigated from the theory of"Yin deficiency",in order to provide more theoretical basis for the research and clinic of this disease.