文献类型：期刊文献

英文题名：Yin-yang effect of tumour cells in breast cancer: from mechanism of crosstalk between tumour-associated macrophages and cancer-associated adipocytes

作者：Zhu, Zhongbo[1];Zhu, Xiangdong[1];Yang, Shuo[1];Guo, Zhanzi[1];Li, Kangle[2];Ren, Cuicui[3];Zhou, Yunyun[4,5];Dou, Jianwei[2]

第一作者：Zhu, Zhongbo

通信作者：Dou, JW[1]

机构：[1]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou 730000, Peoples R China;[2]Xi An Jiao Tong Univ, Sch Pharm, Xian 710061, Peoples R China;[3]Xian 1 Hosp, Dept Pharm, South St Powder Lane 30, Xian 710002, Peoples R China;[4]Xi An Jiao Tong Univ, Affiliated Guangren Hosp, 21 Jiefang Rd, Xian 710004, Peoples R China;[5]Xian Fourth Hosp, Dept Ophthalmol, 21 Jiefang Rd, Xian 710004, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Xi An Jiao Tong Univ, Sch Pharm, Xian 710061, Peoples R China.

年份：2020

卷号：10

期号：2

起止页码：383

外文期刊名：AMERICAN JOURNAL OF CANCER RESEARCH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000518037100002)】；

基金：This work was supported by grants from the National Natural Science Foundation of China (Grant No. 81873311, No. 81573983 and No. 81674028). Zhu Zhongbo thanks to the help provided by School of Pharmacy, Health Science Center, Xi'an Jiaotong University.

语种：英文

外文关键词：Breast cancer; crosstalk; tumour-associated macrophages; cancer-associated adipocytes

摘要：Currently, adipocytes and macrophages are considered to be key cell types of breast cancer (BC) tissues. With the emergence of crown-like structures (CLS), cancer-associated adipocytes (CAAs) and tumour-associated macrophages (TAMs) are formed respectively in tumor microenvironment (TME). Both of them affect the progress of breast cancer, while forming crosstalk in the tumour tissue. CAAs play an important role, which produces hypoxia and inflammation environment and aggravates this environment. The formation and secretion of TAMs with M2 phenotypic characteristics, such as HIF-1 alpha, and TNF-alpha, affect the progress of cancer cells by interfering with the secretion of MCP-1 by CAAs. Therefore, the interaction between CAAs and TAMs may be an effective therapeutic target for breast cancer. In this review, we focus on the biological effects of two types of cells in breast cancer, in order to better explain the crosstalk between them and provide new ideas for the future treatment of breast cancer.