文献类型：期刊文献

中文题名：麻仁丸联合乳果糖对癌痛患者阿片诱导性便秘的预防作用

英文题名：Effect of Maren Pills Combined with Lactulose Preventing Opioid-induced Constipation in Cancer Pain Patients

作者：薛钧[1,2];王道坤[2];刘晶煜[1];朱婷[1];陈梅林[1];李文娟[1]

第一作者：薛钧

机构：[1]兰州大学第二医院宁养院,兰州730030;[2]甘肃中医药大学,兰州730030

第一机构：兰州大学第二医院宁养院,兰州730030

年份：2015

卷号：26

期号：20

起止页码：2835

中文期刊名：中国药房

外文期刊名：China Pharmacy

收录：CSTPCD;;北大核心:【北大核心2014】；

语种：中文

中文关键词：麻仁丸;乳果糖;联合用药;阿片诱导性便秘;便秘评分

外文关键词：Maren pills; Lactulose; Drug combination; Opioid-induced constipation; Constipation score

摘要：目的:观察麻仁丸联合乳果糖对癌痛患者阿片诱导性便秘(OIC)的预防作用。方法:选取281例晚期癌痛患者,按自愿入组方式分为麻仁丸组、乳果糖组、联合用药组。3组患者在应用阿片类药物镇痛的同时分别应用麻仁丸、乳果糖或联合用药(乳果糖服用3 d后换麻仁丸服用3 d,如此往复)来预防性治疗OIC。服药2、4、6周后观察并记录3组患者的便秘程度并进行统计学分析。结果:常规剂量的麻仁丸、乳果糖单用及两药联合应用对预防OIC均有作用,但联合用药对OIC的远期预防作用较好,在服药4、6周时的便秘程度与单用药物组比较,差异均有统计学意义(P<0.05或P<0.01)。结论:麻仁丸联合乳果糖对长期应用阿片类药物镇痛治疗的晚期癌痛患者预防或减轻OIC有明显获益。
OBJECTIVE： To observe the effect of Maren pills combined with lactulose preventing opioid-induced constipation （OIC） in patients with cancer pain. METHODS： 281 cases of advanced cancer pain were selected and divided into March pills group, lactulose group and drug combination group. 3 groups were given opioid to relieve pain, and additionally received Maren pills, lactulose or drug combination （lactulose for 3 d and then Maren pills for 3 d instead, repeated in the same way） to treatment OIC prophylactically. The constipation conditions of 3 groups were observed and recorded at 2, 4 and 6 weeks after the therapy. And then the data were analyzed statistically. RESULTS： The regular doses of Maren pills and lactulose alone or combination had prevention effect on OIC. Drug combination showed better long-term prevention effect; there were statistically significant difference in constipation conditions between grug combination group and other 2 groups after 4 and 6 weeks of therapy （P〈0.05 or P〈 0.01）. CONCLUSIONS： Maren pills combined with lactulose are obvious benefit for constipation prevention and relief in cancer pain patients who use opioid for a long time.