文献类型：期刊文献

英文题名：Gut microbial beta-glucuronidase: a vital regulator in female estrogen metabolism

作者：Hu, Shiwan[1,2];Ding, Qiyou[1,2];Zhang, Wei[1,3];Kang, Mengjiao[3];Ma, Jing[4];Zhao, Linhua[1]

第一作者：Hu, Shiwan

通信作者：Zhao, LH[1]

机构：[1]China Acad Chinese Med Sci, Guang Anmen Hosp, Inst Metab Dis, Beijing, Peoples R China;[2]Beijing Univ Chinese Med, Grad Sch, Beijing, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Sch Basic Med, Lanzhou, Gansu, Peoples R China;[4]Changchun Univ Chinese Med, Coll Tradit Chinese Med, Changchun, Peoples R China

第一机构：China Acad Chinese Med Sci, Guang Anmen Hosp, Inst Metab Dis, Beijing, Peoples R China

通信机构：[1]corresponding author), China Acad Chinese Med Sci, Guang Anmen Hosp, Inst Metab Dis, Beijing, Peoples R China.

年份：2023

卷号：15

期号：1

外文期刊名：GUT MICROBES

收录：;Scopus(收录号：2-s2.0-85167413285);WOS:【SCI-EXPANDED(收录号:WOS:001045275800001)】；

基金：This work was supported by Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine. (Grant No. ZYYCXTD-D-202001).

语种：英文

外文关键词：Gut microbiota; gmGUS; estrobolome; estrogen; GUS gene; beta-glucuronidase; breast cancer; menopausal syndrome; hormone replacement therapy; interaction

摘要：A growing amount of evidence has supported that gut microbiota plays a vital role in the reproductive endocrine system throughout a woman's whole life, and gut microbial beta-glucuronidase (gmGUS) is a key factor in regulating host estrogen metabolism. Moreover, estrogen levels also influence the composition as well as the diversity of gut microbiota. In normal condition, the gmGUS-estrogen crosstalk maintains body homeostasis of physiological estrogen level. Once this homeostasis is broken, the estrogen metabolism will be disturbed, resulting in estrogen-related diseases, such as gynecological cancers, menopausal syndrome, etc. together with gut microbial dysbiosis, which may accelerate these pathological processes. In this review, we highlight the regulatory role of gmGUS on the physical estrogen metabolism and estrogen-related diseases, summarize the present evidence of the interaction between gmGUS and estrogen metabolism, and unwrap the potential mechanisms behind them. Finally, gmGUS may become a potential biomarker for early diagnosis of estrogen-induced diseases. Regulating gmGUS activity or transplanting gmGUS-producing microbes shows promise for treating estrogen-related diseases.