文献类型：期刊文献

英文题名：Kaempferol inhibited invasion and metastasis of gastric cancer cells by targeting AKT/GSK3β pathway based on network pharmacology and molecular docking

作者：Gao, Xia-Qing[1,5];Li, Hai-Long[1,2];Wang, Meng[3,4];Yang, Chun-Ting[1,6];Su, Rong[1];Shao, Li-Hua[1]

第一作者：Gao, Xia-Qing

通信作者：Li, HL[1]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Dept Geriatr, Lanzhou 730000, Peoples R China;[3]Mudanjiang Med Univ, Affiliated Hongqi Hosp, Dept Geriatr, Mudanjiang 157011, Peoples R China;[4]Res Ctr Tradit Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[5]Gansu Univ Chinese Med, Key Lab Gansu Prov Prescript Min, Innovat Translat Lab, Lanzhou 730000, Peoples R China;[6]Gansu Univ Chinese Med, Gansu Prov Tradit Chinese Med New Prod Creat Engn, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2024

外文期刊名：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

收录：;Scopus(收录号：2-s2.0-85201062664);WOS:【SCI-EXPANDED(收录号:WOS:001289944200001)】；

基金：This work was financially supported by the Research Center of Traditional Chinese Medicine, Gansu Province [zyzx-2023-24]; the Lanzhou Science and Technology Development Guidance Plan Project [2023-ZD-224]; the Guiding Projects of the Enshi Tujia and Miao Autonomous Prefecture Science and Technology Plan of Hubei Province [grant no. E20220033].

语种：英文

外文关键词：Kaempferol; gastric cancer; AKT/GSK3 beta signaling pathway; invasion and metastasis; network pharmacology

摘要：This study aims to explore the mechanisms of the inhibitory effect of kaempferol on the invasion and metastasis of gastric cancer (GC) cells through network pharmacology prediction and experimental verification. It identifies core targets via PPI network analysis and finds that kaempferol binds to these targets well. In vitro experiments showed that kaempferol could inhibit the proliferation, colony formation, migration and invasion of GC cells. Western blotting indicated kaempferol may reduce AKT and GSK3 beta phosphorylation, leading to lower expression of invasion-related genes SRC, MMP9, CXCR4, KDR, and MMP2. Overall, kaempferol may prevent migration and invasion of GC cells via the AKT/GSK3 beta signaling pathway.