文献类型：期刊文献

英文题名：LncRNA-mediated cell autophagy: An emerging field in bone destruction in rheumatoid arthritis

作者：Lei, Hai-Tao[1,2,5];Wang, Jin-Hai[3];Yang, Hui-Jun[1,2];Wu, Hai-Juan[1,2];Nian, Fang-Hong[1,2];Jin, Fang-Mei[1,2];Yang, Jing[4];Tian, Xue-Mei[1,2];Wang, Hai-Dong[1,2]

第一作者：Lei, Hai-Tao

通信作者：Tian, XM[1];Wang, HD[1];Tian, XM[2];Wang, HD[2]

机构：[1]Gansu Prov Hosp Tradit Chinese Med, Dept Rheumatol, Lanzhou 730050, Gansu, Peoples R China;[2]Gansu Prov Hosp Tradit Chinese Med, Orthoped Ctr, Lanzhou 730050, Gansu, Peoples R China;[3]Lanzhou Univ, Tradit Chinese Med Dept, Hosp 2, Lanzhou 730030, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[5]Gansu Prov Tradit Chinese Med, 418 Guazhou Rd, Lanzhou, Gansu, Peoples R China

第一机构：Gansu Prov Hosp Tradit Chinese Med, Dept Rheumatol, Lanzhou 730050, Gansu, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Dept Rheumatol, Lanzhou 730050, Gansu, Peoples R China;[2]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Orthoped Ctr, Lanzhou 730050, Gansu, Peoples R China.

年份：2023

卷号：168

外文期刊名：BIOMEDICINE & PHARMACOTHERAPY

收录：;Scopus(收录号：2-s2.0-85174704703);WOS:【SCI-EXPANDED(收录号:WOS:001094613700001)】；

基金：This review was supported by the National Key Research and Development Plan Projects (No. 2018YFC1705203) , Industry Special Project of the State Administration of Traditional Chinese Medicine (No. 20150700107) , and TCM Project from the Administration of Traditional Chinese Medicine of Gansu Provincial Health Commission (No. GZKP-2021-12 and No. GZKZ-2021-3) .

语种：英文

外文关键词：LncRNAs; Autophagy; Bone destruction; Signalling pathway; Rheumatoid arthritis; Review

摘要：In recent years, research on the mechanism of bone destruction in rheumatoid arthritis (RA) has remained in the initial stages, and the mechanism has not been fully elucidated to date. Recent studies have shown that long noncoding RNAs (lncRNAs) participate in RA bone destruction via autophagy, but the specific regulatory mechanism of lncRNA-mediated autophagy is unclear. Therefore, in this article, we review the mechanisms of lncRNA-mediated autophagy in fibroblast-like synoviocytes and chondrocytes in RA bone destruction. We explain that lncRNAs mediate autophagy and participate in many specific pathological processes of RA bone destruction by regulating signalling pathways and the expression of target genes. Specific lncRNAs can be used as markers for molecular diagnosis, mechanistic regulation, treatment and prognosis of RA.