文献类型：期刊文献

英文题名：Ultrasonographic and cytological characterization of ultrasound-guided fine-needle aspiration cytology of cervical lymph nodes for false-negative and false-positive diagnosis

作者：Ren, Yiqun[1];Shi, Yucong[1];Zhou, Zubang[2];Yang, Daxiong[1];Xie, Jinhui[2];Zhang, Zhi[1];Wang, Jiao[3]

第一作者：Ren, Yiqun

通信作者：Zhou, ZB[1]

机构：[1]Gansu Univ Chinese Med, Gansu Prov Hosp, Clin Med Coll 1, Lanzhou, Peoples R China;[2]Gansu Prov Hosp, Dept Ultrasound, 204 West Dong-Gang Rd, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Lanzhou, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Ultrasound, 204 West Dong-Gang Rd, Lanzhou 730000, Gansu, Peoples R China.

年份：2023

卷号：280

期号：5

起止页码：2463

外文期刊名：EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY

收录：;Scopus(收录号：2-s2.0-85144839794);WOS:【SCI-EXPANDED(收录号:WOS:000903984400001)】；

基金：Partial financial support was received from Lanzhou Talent Innovation and Entrepreneurship Project Task Contract (No. 2019-RC -119); National Research Project Incubation Program of Gansu Provincial People's Hospital (No. 19-SYPYB-26).

语种：英文

外文关键词：Cervical lymph nodes; Fine needle aspiration cytology; Ultrasound characteristics; Cytology characteristics; False-negative; False-positive

摘要：Objectives The primary goal of this study was to examine the ultrasound and cytological characteristics of inconsistent cases (false negatives and false positives)of ultrasound-guided fine-needle aspiration cytology (US-FNAC) of cervical lymph nodes, to investigate factors influencing the diagnostic accuracy of fine-needle aspiration, and to improve diagnostic efficiency. Methods The results of US and FNAC of cervical lymph nodes in 562 cases treated at our institution from February 2019 to June 2021 were retrospectively analyzed. FNAC cytology results were compared with the final diagnostic results (242 surgical resections/core-needle biopsy, 320 cases followed up for more than 1 year), and the final diagnostic results were taken as the gold standard, and the ultrasound features and clinicopathology-related features were systematically retrospectively analyzed in cases of inconsistency. Results The overall diagnostic accuracy of US-FNAC for cervical lymph nodes was 94.9%, with a false-negative rate of 6.7% and a false-positive rate of 3.8%. Analyzing the cases, sampling error due to factors associated with ultrasound features, such as larger, more numerous nodes, non-solid, hypoechoic, inhomogeneous, and increased vascularity are the main causes of false-negative diagnosis, while smaller nodules, overlapping cytologic patterns, and overinterpretation by pathologists are associated with false-positive FNAC results. Conclusions Proper interpretation of cytomorphologic and ultrasound features can improve diagnostic accuracy, and diagnostic misdiagnosis should be carefully observed, the identification of both features should be enhanced to reduce interpretation errors and sampling errors and to reduce the rate of misdiagnosis and missed diagnoses in fine needle aspiration of lymph nodes.