文献类型：期刊文献

英文题名：Correlation of hepatitis C genotype with HCV-RNA, RBC-related parameters, and blood platelet count

作者：Zhao, Jing[1,2];Li, Yanrong[3];Liang, He[1];Feng, Ai[2];Hui, Lingyun[2]

第一作者：Zhao, Jing

通信作者：Hui, LY[1]

机构：[1]Dingxi Peoples Hosp, Dingxi, Gansu, Peoples R China;[2]Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Lab Med, Xian 710049, Shaanxi, Peoples R China;[3]Gansu Univ Chinese Med, Coll Basic Med, Lanzhou, Gansu, Peoples R China

第一机构：Dingxi Peoples Hosp, Dingxi, Gansu, Peoples R China

通信机构：[1]corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Lab Med, Xian 710049, Shaanxi, Peoples R China.

年份：2025

卷号：104

期号：28

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-105010752901);WOS:【SCI-EXPANDED(收录号:WOS:001528438200048)】；

基金：This study was supported by the National Natural Science Foundation of China (No. 82360905); Science Technology Project of Shaanxi Province (No. 2023-YBSF-411) and Clinical Research Project of Xi'an Jiaotong University First Affiliated Hospital (No. XJTU1AF-CRF-2017-014).

语种：英文

外文关键词：blood platelet count; genotype; hepatitis C; red blood cell count; virus RNA

摘要：Background: This study aimed to clarify the correlation of hepatitis C genotype with hepatitis C virus (HCV)-RNA, red blood cell (RBC)-related parameters (i.e., RBC count, hemoglobin concentration [HGB], mean corpuscular volume, RBC distribution width-standard deviation, RBC distribution width-coefficient of variability) and blood platelet (PLT) count, providing a reference basis to clinicians for diagnosing and treating hepatitis C. Methods: Hepatitis C genotyping, RBC-related parameters, PLT count, hepatitis C virus ribonucleic acid (HCV-RNA) logarithmic values (lg) and HCV antibodies (anti-HCV; ratio of the measured value to the critical value [S/CO]) were detected in 168 patients with chronic hepatitis C. Results: Compared with the non-type I group, differences were found in HCV-RNA (lg) and anti-HCV in the type I group (P < .05). Compared with the negative group, significant differences were noted in anti-HCV (S/CO) in the type I and non-type I groups (P < .01). The RBC count and HGB of the type I group were significantly lower than those of the non-type I and negative groups. The PLT count of the 3 groups increased sequentially, with all groups exhibiting significant differences (P < .05). HCV-RNA (lg) was significantly negatively correlated with RBC count, HGB and PLT count (P < .05). The analysis of the receiver operating characteristic curve and its area under the curve indicates that RBC count, HGB, mean corpuscular volume reciprocal and PLT count exhibit certain clinical reference value for determining whether HCVs are replicating. Conclusion: Clinicians should closely monitor changes in blood cell-related indicators before and after antiviral treatment and then develop personalized treatment plans for patients.