文献类型：期刊文献

英文题名：Vitamin D deficiency as a risk factor for dementia and Alzheimer's disease: an updated meta-analysis

作者：Chai, Bingyan[1,2];Gao, Fulin[1];Wu, Ruipeng[1];Dong, Tong[1];Gu, Cheng[1];Lin, Qiaoran[1];Zhang, Yi[1]

第一作者：Chai, Bingyan

通信作者：Chai, BY[1];Chai, BY[2]

机构：[1]Gansu Prov Peoples Hosp, Dept Neurol, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Sch Clin Med, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China

第一机构：Gansu Prov Peoples Hosp, Dept Neurol, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Gansu Prov Peoples Hosp, Dept Neurol, 204 Donggang West Rd, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Sch Clin Med, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China.|[10735c1ddf597548aedb5]甘肃中医药大学临床医学院;[10735]甘肃中医药大学;

年份：2019

卷号：19

期号：1

外文期刊名：BMC NEUROLOGY

收录：;Scopus(收录号：2-s2.0-85074959973);WOS:【SCI-EXPANDED(收录号:WOS:000497453600001)】；

基金：This work did not receive any specific grant from funding agencies in the public, commercial, or non-profit sectors.

语种：英文

外文关键词：Alzheimer's disease; Dementia; Vitamin D deficiency; Meta-analysis

摘要：Background We aimed to comprehensively explore the associations between serum 25(OH)D deficiency and risk of dementia and Alzheimer's disease(AD). Methods We systematically searched Pubmed, the Cochrane Library, Embase and the reference lists of pertinent review articles for relevant articles published from database inception up until January 2019. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with random effects models using the Stata 12.0 statistical software package. Results Twelve prospective cohort studies and four cross-sectional studies were included in this meta-analysis. The pooled HRs of dementia and AD, respectively, were 1.32 (95%CI: 1.16, 1.52) and 1.34 (95%CI: 1.13, 1.60) for vitamin D deficiency (< 20 ng/ml). In the subgroup analyses, the pooled HRs of dementia and AD, respectively, were 1.48 (95%CI: 1.19, 1.85) and 1.51 (95%CI: 1.04, 2.18) for moderate vitamin D deficiency (10-20 ng/ml) and 1.20 (95%CI: 0.99, 1.44) and 1.36 (95%CI: 1.01, 1.84) for severe vitamin D deficiency (< 10 ng/ml). Conclusion There are significant associations between vitamin D deficiency and both dementia and AD. There are stronger associations between severe vitamin D deficiency (< 10 ng/ml) and both dementia and AD compared to moderate vitamin D deficiency (10-20 ng/ml).