文献类型：期刊文献

英文题名：The impact of pelvic radiotherapy on the gut microbiome and its role in radiation-induced diarrhoea: a systematic review

作者：Wang, Lina[1,2];Wang, Xiaohu[2,3,5];Zhang, Guangwen[4];Ma, Yan[1,2];Zhang, Qiuning[3];Li, Zheng[3];Ran, Juntao[1];Hou, Xiaoming[1];Geng, Yichao[2];Yang, Zheng[2,3];Feng, Shuangwu[2];Li, Chengcheng[2];Zhao, Xueshan[2]

第一作者：Wang, Lina

通信作者：Wang, XH[1];Wang, XH[2];Wang, XH[3]

机构：[1]Lanzhou Univ, Dept Radiat Oncol, Hosp 1, Lanzhou, Peoples R China;[2]Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China;[3]Chinese Acad Sci, Biomed Ctr, Inst Modern Phys, Dept Radiat Med, Yanbei Rd, Lanzhou 730000, Gansu, Peoples R China;[4]Gansu Univ Chinese Med, Affiliated Hosp, Lanzhou, Peoples R China;[5]Lanzhou Heavy Ion Hosp, Dept Radiat Therapy, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Dept Radiat Oncol, Hosp 1, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Sch Clin Med 1, Lanzhou, Peoples R China;[2]corresponding author), Chinese Acad Sci, Biomed Ctr, Inst Modern Phys, Dept Radiat Med, Yanbei Rd, Lanzhou 730000, Gansu, Peoples R China;[3]corresponding author), Lanzhou Heavy Ion Hosp, Dept Radiat Therapy, Lanzhou, Peoples R China.

年份：2021

卷号：16

期号：1

外文期刊名：RADIATION ONCOLOGY

收录：;Scopus(收录号：2-s2.0-85116292415);WOS:【SCI-EXPANDED(收录号:WOS:000699010600001)】；

基金：This work was supported by the Natural Science Foundation of China Regional Science Foundation Project under Grant No. 82060553, Talent Innovation and Venture Project of Lanzhou City under Grant No. 2017-RC-23, the Hospital Fund Project of the First Hospital of Lanzhou University under Grant No. ldyyyn2018-09], and the Lanzhou Science and Technology Development Guiding Project under Grant No. 2019-ZD-45.

语种：英文

外文关键词：Radiotherapy; Gastrointestinal microbiome; Diarrhoea; Systematic review

摘要：Pelvic radiotherapy is the key treatment for pelvic malignancies, usually including pelvic primary tumour lesions and lymphatic drainage areas in the pelvic region. Therefore, the intestinal tract in the radiation field is inevitably damaged, a phenomenon clinically referred to as radiation enteritis, and diarrhoea is the most common clinical symptom of radiation enteritis. Therefore, it is necessary to study the mechanism of radiation-induced diarrhoea. It has been found that the gut microbiome plays an important role in the development of diarrhoea in response to pelvic radiotherapy, and the species and distribution of intestinal microbiota are significantly altered in patients after pelvic radiotherapy. In this study, we searched for articles indexed in the Cochrane Library, Web of Science, EMBASE and PubMed databases in English and CNKI, Wanfang data and SINOMED in Chinese from their inception dates through 13 March 2020 to collect studies on the gut microbiome in pelvic radiotherapy patients. Eventually, we included eight studies: one study report on prostatic carcinoma, five studies on gynaecological carcinoma and two papers on pelvic carcinomas. All studies were designed as self-controlled studies, except for one that compared toxicity to nontoxicity. The results from all the studies showed that the diversity of intestinal flora decreased during and after pelvic radiotherapy, and the diversity of intestinal flora decreased significantly in patients with diarrhoea after radiotherapy. Five studies observed that the community composition of the gut microbiota changed at the phylum, order or genus level before, during, and after pelvic radiotherapy at different time points. In addition, the composition of the gut microbiota before radiotherapy was different between patients with postradiotherapy diarrhoea and those without diarrhoea in five studies. However, relevant studies have not reached consistent results regarding the changes in microbiota composition. Changes in the intestinal flora induced by pelvic radiotherapy and their relationship between changes in intestinal flora and the occurrence of radiation-induced diarrhoea (RID) are discussed in this study, providing a theoretical basis for the causes of RID after pelvic radiotherapy.