文献类型：期刊文献

英文题名：Impact of Nocturnal Environmental Noise on Phosphorylated Protein Kinase C Epsilon Pathway and Warmth Acupuncture Efficacy in Patients with Migraine

作者：Liu, Qiang[1,2];Qin, XiaoGuang[1,2];Luo, ChengLin[1,2];Zhao, ZhongTing[1,2];Xie, WangJun[1,2];Qin, Xin[3];Du, XiaoZheng[1,2]

第一作者：刘强

通信作者：Du, XZ[1];Du, XZ[2];Qin, X[3]

机构：[1]Gansu Univ Tradit Chinese Med, Dept Acupuncture, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Moxibust Massage Coll, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[3]Second Peoples Hosp Gansu Prov, Dept Funct, 1 Hezheng West St, Lanzhou 730000, Gansu, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Tradit Chinese Med, Dept Acupuncture, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Moxibust Massage Coll, 35 Dingxi East Rd, Lanzhou 730000, Gansu, Peoples R China;[3]corresponding author), Second Peoples Hosp Gansu Prov, Dept Funct, 1 Hezheng West St, Lanzhou 730000, Gansu, Peoples R China.|[10735]甘肃中医药大学;

年份：2025

卷号：27

期号：129

起止页码：842

外文期刊名：NOISE & HEALTH

收录：;Scopus(收录号：2-s2.0-105026517410);WOS:【SCI-EXPANDED(收录号:WOS:001653155000025)】；

基金：This study was supported by the Gansu Provincial Department of Education 2020 Innovation Ability Improvement Project: The Regulation Mechanism of PKCPathway in Migraine Model Rats under the Intervention ofWentong Acupuncture Based on the Theory of PainSensitivity. PKC Pathway Regulation Mechanism (No.2020B-52).

语种：英文

外文关键词：migraine; noise; protein kinase c epsilon; acupuncture therapy; pain management

摘要：Background: Environmental noise exposure is a potential trigger, potentially exacerbating migraine through stress-related activation of phosphorylated protein kinase C epsilon (PKC epsilon)-mediated nociceptive pathways. Warmth acupuncture therapy offers a potential complementary treatment. This study investigates the effect of nocturnal noise on PKC epsilon markers and the efficacy of warmth acupuncture in patients with migraine. Methods: A retrospective cohort study of 220 patients with migraine was conducted. The patients were divided into two groups based on nocturnal noise exposure: low noise [<= 45 dB(A), n = 110] and high noise [>45 dB(A), n = 110]. Both groups received warmth acupuncture. Pain, sleep, anxiety, and biochemical markers (p-PKC epsilon, phosphorylated cyclic adenosine monophosphate (cAMP) response element binding protein and phosphorylated signal transducer and activator of transcription 1) were evaluated before and after 1 month of therapy. Continuous variables were compared using independent t-tests, and categorical variables were compared using chi-square tests. Pearson's correlation analysis was used to assess relationships between noise levels and PKC epsilon pathway markers. Results: After 1 month, the low-noise group was associated with significantly more favorable distribution of migraine symptom severity, lower visual analog scale pain scores, better sleep quality, lower anxiety levels, and lower PKC epsilon pathway marker expression than the high-noise group (P < 0.05 for all). Correlation analysis revealed that higher noise levels were significantly associated with increased PKC epsilon pathway markers. Conclusion: Lower nocturnal noise levels were associated with greater treatment response to warmth acupuncture and reduced PKC epsilon pathway activation, suggesting that environmental noise may play an important role in migraine pathophysiology.