文献类型：期刊文献

英文题名：Catalytic asymmetric synthesis strategies of helically chiral molecules

作者：Zhang, Jingying[1,2]; Xiao, Jianzhe[2]; Xu, Yun[3,4]; Liu, Xihong[2]

第一作者：Zhang, Jingying

机构：[1] Research and Experimental Center, Gansu University of Chinese Medicine, Lanzhou, 730000, China; [2] Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China; [3] Department of Respiratory and Critical Care Medicine, Center for Oncology Medicine, The Fourth Affiliated Hospital of School of Medicine, International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China; [4] Zhejiang Key Laboratory of Precision Diagnosis and Treatment for Lung Cancer, Yiwu, 322000, China

第一机构：甘肃中医药大学

通信机构：[3]Department of Respiratory and Critical Care Medicine, Center for Oncology Medicine, The Fourth Affiliated Hospital of School of Medicine, International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China

年份：2026

外文期刊名：Trends in Chemistry

收录：EI(收录号：20263721451221);Scopus(收录号：2-s2.0-105049579139)

语种：英文

外文关键词：Catalysis - Chirality - Indium compounds - Molecules - Stereochemistry - Synthesis (chemical)

摘要：Catalytic asymmetric synthesis serves as a powerful strategy for producing optically active molecules. While breakthroughs in central, axial, and planar chirality have laid a solid foundation for exploring helical chirality, this field still lags behind in available synthetic methods and in quantity. Despite recent achievements, a systematic review focusing on the asymmetric construction of helical core frameworks remains notably absent. This review provides an in-depth overview of strategies and detailed examples for synthesizing helicenes and helicene-like molecules. It delves into underlying mechanisms and highlights persistent challenges in this demanding field. By synthesizing current knowledge and outlining future directions, this review aims to accelerate breakthroughs and promote a more balanced advancement across all classes of chiral compounds. ? 2026 Elsevier Inc.