文献类型：期刊文献

英文题名：Traditional Chinese medicine for mild cognitive impairment A protocol for systematic review and network meta-analysis

作者：Wang, Haiyan[1,2];Yu, Haiyang[3];Song, Kai[1];Xiong, Fanjie[1];Zhang, Hong[1]

第一作者：汪海燕;Wang, Haiyan

通信作者：Zhang, H[1]

机构：[1]Chengdu Univ Tradit Chinese Med, Coll Acupuncture & Tuina, Chengdu, Sichuan, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Dept Acupuncture & Moxibust, Affiliated Hosp, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Dept Traumat Orthoped, Affiliated Hosp, Lanzhou, Gansu, Peoples R China

第一机构：Chengdu Univ Tradit Chinese Med, Coll Acupuncture & Tuina, Chengdu, Sichuan, Peoples R China

通信机构：[1]corresponding author), Chengdu Univ Tradit Chinese Med, Coll Acupuncture & Tuina, Chengdu, Sichuan, Peoples R China.

年份：2020

卷号：99

期号：37

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85091054320);WOS:【SCI-EXPANDED(收录号:WOS:000579180600083)】；

基金：This study was supported by the Sichuan Science and Technology Department planned project (No.2018SZ0072).

语种：英文

外文关键词：mild cognitive impairment; protocol; systematic review; traditional Chinese medicine therapies

摘要：Background: Mild cognitive impairment (MCI) is an intermediate stage between normal aging and Alzheimer disease, which is the most common form of dementia in the world. In clinical practice, traditional Chinese medicine (TCM) interventions have been administered for MCI, However, there is still uncertain about what strategy of TCM interventions treatment should be preferred in clinical practice. This study aims to evaluate the efficacy and acceptability of different TCM therapies through systematic review and network meta-analysis. Methods: According to the strategy, the authors will retrieve a total of 7 electronic databases by August 2020, including PubMed, the Cochrane Library, EMbase, China National Knowledge Infrastructure, China Biological Medicine, Chongqing VIP, and Wan-fang databases. After a series of screening, 2 researchers will use Aggregate Data Drug Information System and Stata software to analyze the data extracted from the randomized controlled trials of TCM therapies for MCI. The primary outcome of this study is the improvement of cognitive function and the secondary outcome is the activities of daily living, clinical efficacy, and adverse events, and the quality of the evidence will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation instrument. Results: This study will provide a reliable evidence for the selection of TCM therapies in the treatment of MCI. Conclusion: This study will generate evidence for different TCM therapies for MCI and provide a decision-making reference for clinical research. Ethics and dissemination: This study does not require ethical approval. The results will be disseminated through a peer-reviewed publication. OSF registration number: DOI 10.17605/OSF.IO/JV9KG.