文献类型：期刊文献

中文题名：重构本草——熟地黄

英文题名：Reconstruction of Chinese materia medica——prepared rehmannia root

作者：田传玺[1,2];张伟[3];张宇昕[2,4];万砺[2,4];赵林华[2]

第一作者：田传玺

机构：[1]北京中医药大学,北京100029;[2]中国中医科学院广安门医院代谢病研究所,北京100053;[3]甘肃中医药大学基础医学院,兰州730000;[4]中国中医科学院广安门医院,北京100053

第一机构：北京中医药大学,北京100029

年份：2023

卷号：43

期号：5

起止页码：596

中文期刊名：吉林中医药

外文期刊名：Jilin Journal of Chinese Medicine

收录：CSTPCD

基金：中国科学院学部咨询评议项目(2021-ZW10-A-017)。

语种：中文

中文关键词：熟地黄;症靶;标靶;咳喘;耳鸣;腰痛;月经不调;血红蛋白;血小板;临床回归

外文关键词：prepared rehmannia root;symptom target;biochemical indicator target;cough and asthma;tinnitus;lumbago;menstrual disorders;hemoglobin;platelet;clinical verification

摘要：通过古籍文献调研、中药现代研究进展及其研究成果的梳理,结合中医临床及中药学等学科领域内的专家学者的认识及应用经验,经讨论认为熟地黄功效主要为补血滋阴,益精填髓。症靶为肾虚咳喘、肾虚耳鸣、肾虚腰痛、月经不调。标靶为低血红蛋白和低血小板。现代药理研究发现熟地黄及其有效成分具有抗氧化、抗衰老、抗焦虑、增强记忆力、促进造血、降血糖、降血脂、抗肿瘤、耐缺氧、促进肝糖元合成等作用。凡气滞痰多、脘腹胀痛、食少便溏者忌服。重用久服宜与陈皮、砂仁等同用,以免黏腻碍胃。临床使用剂量为1~120 g,若应用大剂量熟地黄,常同时增加泽泻用量以利湿泄浊,防止熟地黄滋腻恋邪。同时可根据不同疾病,或同一疾病的不同阶段进行辨证使用,切莫刻意追求大剂量使用,并积极探索熟地黄用量与症靶、标靶的量效关系构建。
Based on the investigation of ancient books and literature,the progress and achievements of modem research on traditional Chinese medicine,and the understanding and application experience of experts and scholars in the fields of clinical Chinese medicine and Chinese materia medica,it is believed that prepared rehmannia root mainly has the effects of tonifying blood and nourishing yin,benefiting the essence and replenishing marrows.Its symptom targets are cough and asthma due to kidney deficiency,tinnitus due to kidney deficiency,lumbago due to kidney deficiency and menstrual disorders,while its biochemical indicator targets are low hemoglobin and low platelets.The modem pharmacological study has found that prepared rehmannia root and its effective components play a role in anti-oxidation,anti-aging,anti-anxiety,enhancing memory,promoting hematopoiesis,lowering blood glucose,lowering blood lipids,anti-tumor,anti-hypoxia,promoting liver glycogen synthesis,etc.It is contraindicated for people with qi stagnation and excessive phlegm,distensions and pains in the abdomen,and loose stools.It is advisable to use it together with dried tangerine peel and villous amomum fruit when it is used in a large dose and for a long time to avoid sticking and obstructing the stomach.Its clinical dosage range is 1-120 g.If a large dose ofprepared rehmannia root is used,the dosage of oriental waterplantain rhizome needs to be increased at the same time to promote diuresis and eliminate turbidity,so as to prevent it from nourishing and producing damp pathogens.Meanwhile,it should be used according to different diseases or different stages ofthe same disease,and the dose-effect relationship between its dosage and its symptom and biochemical indicator targets should be actively explored and constructed.