文献类型：期刊文献

中文题名：运动性软骨损伤的问题及潜在性治疗方案

英文题名：Current problems and potential treatment options for sports cartilage injury

作者：石松源[1];彭志辉[2]

第一作者：石松源

机构：[1]兰州理工大学体育部,甘肃省兰州市730050;[2]甘肃中医药大学体育健康学院,甘肃省兰州市730000

第一机构：兰州理工大学体育部,甘肃省兰州市730050

年份：2019

卷号：23

期号：31

起止页码：5059

中文期刊名：中国组织工程研究

外文期刊名：Chinese Journal of Tissue Engineering Research

收录：CSTPCD;;北大核心:【北大核心2017】；

基金：国家自然科学基金项目(81560791),项目参与人:彭志辉;兰州市2015年第二批科技计划项目(2015-2-81),项目负责人:彭志辉~~

语种：中文

中文关键词：关节软骨损伤;运动;治疗;生物打印;凋亡细胞;软骨祖细胞;国家自然科学基金

外文关键词：articular cartilage injury;exercise;treatment;bioprinting;apoptotic cells;cartilage progenitor cells;the National Natural Science Foundation of China

摘要：背景:关节软骨损伤在运动中非常普遍,主要由慢性关节应力或急性创伤性扭伤引起,往往会导致关节功能进行性损害,并限制相关运动和锻炼的参与。现有的关节软骨修复技术可以修复高冲击运动所致的关节软骨损伤,但这种治疗方法不产生正常的关节软骨,限制了软骨修复的成功率和耐久性。目的:综述近年国内外治疗运动性软骨损伤中出现的问题及潜在性的治疗进展。方法:以"运动""软骨""回顾""治疗"为中文关键词,在中国知网、维普、万方等中文数据库进行检索,并以"cartilage""exercise""review""back pain""treat"作为外文关键词,在PubMed、Google Scholar、Web of Science等数据库进行检索,重点筛选近5年的文献,检索文献语种为中文和英文。共检得文献627篇,依据纳入和排除标准,最终纳入相关文献44篇。结果与结论:(1)治疗运动性关节软骨损伤的目标是减少疼痛,改善膝关节功能,最重要的是让运动员恢复到受伤前的运动水平;(2)目前已有一些手术技术已经实现可变耐用的关节软骨修复,让运动员重返体育运动和锻炼,然而手术不会产生完全正常的透明软骨;(3)研究发现,关节软骨中存在软骨祖细胞,具有迁移行为、多分化能力和克隆形成性,由于不同性质和程度的机械损伤刺激软骨祖细胞,导致凋亡0细胞释放化学引诱物,从而分化成软骨原细胞,修复损伤软骨;(4)基于此,生物打印富含软骨祖细胞的特异性骨软骨结构,以替代受损关节仍是未来的潜在性战略方案。
BACKGROUND: Articular cartilage damage is very common in exercise and is mainly caused by chronic joint stress or acute traumatic sprain, which often leads to progressive damage of joint function and limits the participation of related exercise and exercise. The existing articular cartilage repair technique can repair articular cartilage damage caused by high impact exercise, but this treatment cannot produce normal articular cartilage, which limits the success rate and durability of cartilage repair.OBJECTIVE: To review the problems and potential treatment progress in the treatment of sports cartilage injury at home and abroad in recent years.METHODS: CNKI, VIP, WanFang, PubMed, Google Scholar, and Web of Science databases were retrieved using the keywords of "cartilage,exercise, review, back pain, treat" in Chinese and English, respectively, focusing on the selection of literature published in the past 5 years. A total of 627 articles were searched, and 44 eligible articles were included based on inclusion and exclusion criteria.RESULTS AND CONCLUSION:(1) The goal of treating sports articular cartilage injury is to alleviate pain, improve knee function, and most importantly, to restore athletes to the level of exercise before injury.(2) At present, some surgical techniques have been implemented to achieve variable and durable articular cartilage repair, allowing athletes to return to sports and exercise. However, surgery does not produce completely normal hyaline cartilage.(3) It has been found that cartilage progenitor cells exist in articular cartilage, and have migration behavior, multi-differentiation ability and colony formation ability. Because mechanical injuries with different characteristics and intensities simulate cartilage progenitor cells, so apoptotic cells release inducers, thus differentiating into chondroblasts to repair injured cartilage.(4)Thereafter, bioprinting of specific osteochondral structures rich in cartilage progenitor cells to replace damaged joints remains a potential strategy in the future.