文献类型：期刊文献

中文题名：敦煌石室大宝胶囊对衰老大鼠脑组织单胺类神经递质的影响

英文题名：Effect of Dunhuang Shishi Dabao capsule on monoamine neurotransmitter in brain tissue of aging model rats

作者：程容[1];段永强[1];成映霞[1];梁玉杰[1];王道坤[1]

第一作者：程容

机构：[1]甘肃中医学院基础课部

第一机构：甘肃中医药大学

年份：2010

期号：4

起止页码：478

中文期刊名：中国老年学杂志

外文期刊名：Chinese Journal of Gerontology

收录：北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：甘肃省科技攻关计划项目(2GS064-A43-020-22);兰州市科技局计划项目(06-2-87)

语种：中文

中文关键词：单胺类神经递质;衰老模型;大鼠;敦煌石室大宝胶囊

外文关键词：Monoamine neurotransmitter; Aging model; Rats; Dunhuang Shishi Dabao Capsule （DHDB）

摘要：目的观察敦煌石室大宝胶囊(DHDB)对衰老模型大鼠脑组织单胺类神经递质去甲肾上腺素(NE)、多巴胺(DA)和5-羟色胺(5-HT)含量的影响。方法采用D-半乳糖建立大鼠衰老模型,测定大脑皮层内的NE、DA和5-HT含量。结果模型组大鼠脑组织内NE、DA、5-HT含量与空白组比较均有明显降低(P<0.05),应用DHDB治疗后,治疗组大鼠脑组织内NE、DA、5-HT含量均显著增高(P<0.05)。结论DHDB可提高衰老模型动物脑组织单胺类神经递质的含量,对改善大脑功能有一定的作用。
Objective To explore the effect of Dunhuangdabao （DHDB） on monoamine neurotransmitter norepinephrine （NE） ,dopamine （DA） and 5-hydroxytryptamine （5-HT） levels in the brain tissue of aging model rats. Methods The subacutely aging model rats were made by injecting D-gal into abdominal cavity continually,and cerebral cortex NE,DA,and 5-HT levels were evaluated. Results The NE,DA and 5-HT levels in model group were significantly downregulated compared with those in normal group （P0.05,P0.05,P0.05）. After treated with DHDB,NE,DA and 5-HT levels were significantly upregulated （P0.05,P0.05,P0.05）. Conclusions DHDB can upregulate monoamine neurotransmitter levels in the brain tissue of aging model rats and plays an important role in improving cerebral function.