文献类型：期刊文献

英文题名：Blocking of STAT-3/SREBP1-mediated glucose-lipid metabolism is involved in dietary phytoestrogen-inhibited ovariectomized-induced body weight gain in rats

作者：Chen, Juan[1];Yue, Jia[2];Liu, Yun[1];Liu, Jiao[1];Jiao, Kailin[1];Teng, Mengying[1];Hu, Chunyan[1];Zhen, Jing[1];Wu, Maoxuan[1];Li, Zhong[1];Li, Yuan[1]

第一作者：Chen, Juan

通信作者：Li, Z[1];Li, Y[1]

机构：[1]Nanjing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Nanjing 211166, Jiangsu, Peoples R China;[2]Gansu Univ Chinese Med, Sch Publ Hlth, Dept Nutr & Food Hyg, Lanzhou 730000, Gansu, Peoples R China

第一机构：Nanjing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Nanjing 211166, Jiangsu, Peoples R China

通信机构：[1]corresponding author), Nanjing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Nanjing 211166, Jiangsu, Peoples R China.

年份：2018

卷号：61

起止页码：17

外文期刊名：JOURNAL OF NUTRITIONAL BIOCHEMISTRY

收录：;Scopus(收录号：2-s2.0-85052887151);WOS:【SCI-EXPANDED(收录号:WOS:000451791100002)】；

基金：This work was supported by National Natural Science Foundation of China (81573183 and 81673205), the Major Program of Natural Science Research of Jiangsu Higher Education Institutions (15KJA330001), the project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), and the Gansu Provincial Natural Science Foundation (148RJZA081) and the project of Lanzhou Science and Technology (2014-1-18).

语种：英文

外文关键词：Glucose-lipid metabolism; Weight gain; Dietary phytoestrogens; Hepatic lipogenesis; Signal transducer and activator of transcription 3

摘要：Postmenopausal women have a decline in circulating estrogen levels and are more prone to obesity and its related metabolic diseases than premenopausal women are. The absence of safe and effective conventional treatments for postmenopausal obesity has changed the focus to natural products as alternative remedies. Here, ovariectomized rats and LO2 cells were used to study the molecular basis of the effect of dietary phytoestrogens on body weight gain and hepatic steatosis. Dietary phytoestrogens can inhibit ovariectomy (OVX)-induced body weight gain, blood glucose concentration, expression of hepatic lipogenic genes, such as sterol regulatory element binding protein (SREBP)1, acetyl-CoA carboxylase (ACC)1, fatty acid synthase (FAS), and stearoyl-CoA desaturase (SCD)1, and decrease liver triglyceride (TG) content, but later estradiol withdrawal increased expression of SREBP1. Histological analysis of liver showed that dietary phytoestrogens improved OVX-induced morphological abnormalities. OVX and high glucose-induced phosphorylation of signal transducer and activator of transcription (STAT)-3 were inhibited by phytoestrogens treatment. In LO2 cells, inhibition of STAT-3 by siRNA attenuated the increased TG content and expression of SREBP1 induced by high glucose. Phytoestrogens reduced the upregulation of SREBP1 and TG induced by high glucose in LO2 cells. In conclusion, these findings illustrated that dietary phytoestrogens markedly alleviated the derangement of lipid metabolism. The underlying mechanism is probably associated with regulating STAT-3/SREBP1 signaling. (C) 2018 Elsevier Inc. All rights reserved.