文献类型：期刊文献

英文题名：Asymmetric total synthesis strategies of halichlorine and pinnaic acid

作者：Liu, Lu[1];Jiang, Minghua[1];Zhang, Qingkang[1];Chen, Hong[1];Zhang, Yifu[1,2];Zhang, Jian[1,2,3]

第一作者：刘璐

通信作者：Zhang, YF[1];Zhang, J[1];Zhang, YF[2];Zhang, J[2];Zhang, J[3]

机构：[1]Gansu Univ Chinese Med, Sch Pharm, Lanzhou 730000, Peoples R China;[2]Northwest Collaborat Innovat Ctr Tradit Chinese Me, Lanzhou 730000, Peoples R China;[3]Coll Gansu Prov, Key Lab Chem & Qual TCM, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Sch Pharm, Lanzhou 730000, Peoples R China;[2]corresponding author), Northwest Collaborat Innovat Ctr Tradit Chinese Me, Lanzhou 730000, Peoples R China;[3]corresponding author), Coll Gansu Prov, Key Lab Chem & Qual TCM, Lanzhou 730000, Peoples R China.|[10735]甘肃中医药大学;

年份：2023

卷号：13

期号：48

起止页码：33754

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20234715093589);Scopus(收录号：2-s2.0-85177177566);WOS:【SCI-EXPANDED(收录号:WOS:001103463400001)】；

基金：This work was supported by the National Natural Science Foundation of China (21562001), the Natural Science Foundation of Gansu Province (22JR5RA586) and the Educational Science and Technology Innovation Program of Gansu Province (2021CYZC-13).

语种：英文

外文关键词：Bioactivity - Marine biology - Metabolites - Musculoskeletal system - Synthesis (chemical)

摘要：Halichlorine and pinnaic acid are structurally related natural alkaloids isolated from different marine organisms. These two marine alkaloids bearing a 6-azaspiro[4.5]decane skeleton demonstrate a wide range of biological effects. It is this kind of unique structure and potentially valuable biological activity that have prompted strong synthetic interest, making it a research focus in recent years. Since the first total synthesis of halichlorine and pinnaic acid completed by Danishefsky's group, many groups have reported their outstanding synthesis methods especially the asymmetric synthesis strategies. This review summarizes the asymmetric synthesis strategies of halichlorine and pinnaic acid using a 6-azaspiro[4.5]decane skeleton as the key intermediate, which can provide some guidance for related work. Halichlorine and pinnaic acids are structurally related to natural alkaloids isolated from different marine organisms. This review summarizes the asymmetric synthesis strategies of halichlorine and pinnaic acid using a 6-azaspiro[4.5]decane skeleton as the key intermediate.