文献类型：期刊文献

英文题名：Short-chain fatty acid metabolism in acute lung injury and intervention strategies from traditional Chinese medicine

作者：Zhao, Bing[1];Li, Rongrong[1];Chen, Dandan[2];Li, Jiangnan[3];Li, Yaya[1];Shen, Ke[2];Zhang, Lumei[1];Xie, Yitong[1];Liu, Yongqi[5];Xiu, Minghui[2];He, Jianzheng[5,6];Zhang, Zhiming[4]

第一作者：赵博

通信作者：Zhang, ZM[1];He, JZ[2]

机构：[1]Gansu Univ Chinese Med, Sch Clin Chinese Med, Lanzhou 730000, Peoples R China;[2]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Peoples R China;[3]Gansu Univ Chinese Med, Sch Basic Med, Lanzhou 730000, Peoples R China;[4]Gansu Prov Hosp Tradit Chinese Med, Lanzhou 730000, Peoples R China;[5]Gansu Basic Disciplines Res Ctr Dunhuang Med, Lanzhou 730000, Peoples R China;[6]Gansu Univ Chinese Med, Res & Expt Ctr, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp Tradit Chinese Med, Lanzhou 730000, Peoples R China;[2]corresponding author), Gansu Basic Disciplines Res Ctr Dunhuang Med, Lanzhou 730000, Peoples R China.

年份：2027

卷号：372

外文期刊名：JOURNAL OF ETHNOPHARMACOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001829383600001)】；

基金：This work was supported by the National Natural Science Foundation of China (No. 82460925), Gansu Provincial Key Research and Development Program (Science and Technology Plan) (No. 26YFFA002), The first batch of Gansu Province "Silver-age Expert Studios" (No. [2025]4 issued by the Provincial Party Committee Talent Group), Gansu Provincial Natural Science Foundation (No. 25JRRA1177).

语种：英文

外文关键词：Acute lung injury; Short-chain fatty acid; Gut microbiota; Traditional Chinese medicine

摘要：Ethnopharmacological relevance: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe conditions associated with high mortality rates and limited treatment options. Short-chain fatty acids (SCFAs) serve as central immunomodulatory metabolites mediate the crosstalk between the gut and lung. Traditional Chinese medicine (TCM), with its holistic approach, shows promise in restoring gut-lung balance and alleviating respiratory inflammation by modulating gut microbiota and SCFA metabolism. Aim of the study: To elucidate the protective role and mechanism of SCFAs in ALI and ARDS via the gut-lung axis. Meanwhile, to evaluate the therapeutic potential of TCM in treating ALI by modulating the gut microbiota and enhancing SCFA production. Methods: A comprehensive literature search was conducted across PubMed, Ovid-Embase, Web of Science, and CNKI databases (2010-2025). Keywords included "short-chain fatty acid", "gut microbes", "acute lung injury", "traditional Chinese medicine", and related terms. The search focused on preclinical and mechanistic studies investigating SCFA signaling, gut microbiota remodeling, and the therapeutic effects of herbal compounds or their active constituents in ALI/ARDS models. Results: This review identified acetate, propionate, and butyrate as key mediators that protect against ALI through distinct mechanisms, including anti-oxidation, anti-inflammation, immunomodulation, apoptosis reduction, airway tight-junction protection, and regulation of intestinal homeostasis. In addition, 9 bioactive components, 5 single-herb extracts, and 4 Chinese herb formulations were found to ameliorate ALI by enriching SCFA-producing bacteria, such as Akkermansia, Lactobacillus, and Lachnospiraceae, thereby elevating systemic and local levels of acetate, propionate, and butyrate. Conclusion: SCFAs represent critical molecular mediators of the gut-lung axis, and their modulation by natural products offers a promising microbiota-centered strategy for ALI treatment. This microbiota-centered strategy holds great promise for ALI precision medicine.