文献类型：期刊文献

中文题名：温通针法辅助治疗老年原发性骨质疏松伴肠功能障碍:随机对照研究

英文题名：Adjuvant therapy of Wentong acupuncture for elderly patients of primary osteoporosis with intestinal dysfunction: a randomized controlled trial

作者：姚小强[1,2];郑先丽[1,2];高佳星[3];周亚婕[3]

第一作者：姚小强

机构：[1]甘肃中医药大学附属医院针灸中心,兰州730000;[2]甘肃省皇甫谧针灸医院,兰州730000;[3]甘肃中医药大学针灸推拿学院

第一机构：甘肃中医药大学第二附属医院

年份：2020

卷号：40

期号：9

起止页码：942

中文期刊名：中国针灸

外文期刊名：Chinese Acupuncture & Moxibustion

收录：CSTPCD;;Scopus;北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；PubMed;

基金：甘肃省高等学校创新能力提升项目:2019A-081;甘肃中医药大学附属医院院内创新基金项目:gzfy-2018-06。

语种：中文

中文关键词：原发性骨质疏松;肠功能障碍;温通针法;骨密度(BMD);骨代谢

外文关键词：primary osteoporosis;intestinal dysfunction;Wentong acupuncture;bone mineral density(BMD);bone metabolism

摘要：目的:观察温通针法对老年原发性骨质疏松(OP)伴肠功能障碍患者骨密度、骨代谢水平及肠道功能的影响。方法:将128例老年原发性OP伴肠功能障碍患者随机分为观察组和对照组,各64例。对照组给予口服维D钙咀嚼片,每次0.6g,每日1次;骨化三醇胶丸每次0.25μg,每日3次,共治疗6个月。在对照组治疗基础上,观察组予温通针法治疗,穴取肾俞、命门、脾俞、大肠俞、天枢、足三里等,每次治疗30min,每日1次,治疗1周后休息2d,连续治疗6个月。治疗前后采用双能X线骨密度仪检测两组患者腰椎、股骨颈、股骨粗隆骨密度(BMD),ELISA法检测血清骨代谢指标[骨碱性磷酸酶(NBAP)、骨钙素(OC)、基质金属蛋白酶-2(MMP-2)、降钙素(CT)]水平,比较两组患者治疗前后肠道功能主要症状评分、血清二胺氧化酶(DAO)及D-乳酸(D-Lac)水平,并评价两组临床疗效。结果:观察组总有效率为85.9%(55/64),高于对照组的71.9%(46/64,P<0.05)。治疗后两组患者各部位BMD均增加(P<0.05)、血清骨代谢指标均改善(P<0.05);且观察组各部位BMD及血清骨代谢指标均优于对照组(P<0.05)。治疗后观察组患者肠道功能主要症状评分,血清DAO、D-Lac水平下降(P<0.05);且观察组各指标均低于对照组(P<0.05)。结论:温通针法辅助治疗老年原发性OP伴肠功能障碍患者能够增加其骨密度、改善骨代谢、调节肠道功能。
Objective To observe the effects of Wentong acupuncture on bone mineral density(BMD),bone metabolism and intestinal function in elderly patients of primary osteoporosis with intestinal dysfunction.Methods A total of 128 elderly patients of primary osteoporosis with intestinal dysfunction were randomly divided into an observation group and a control group,64 cases in each group.Patients in the control group were treated with oral administration of vitamin D calcium chewable tablets(0.6 g,once a day)and calcitriol capsules(0.25μg,three times a day);the treatment was given for 6 months.On the basis of the treatment in the control group,patients in the observation group were additionally treated with Wentong acupuncture at Shenshu(BL 23),Mingmen(GV 4),Pishu(BL 20),Dachangshu(BL 25),Tianshu(ST 25)and Zusanli(ST 36),etc.for 30 min each time,once a day.After 1-week treatment,the patients took a rest for 2 days;the treatment was given for 6 months.Before and after treatment,the BMD of lumbar spine,femoral neck and femoral trochanter was detected by dual energy X-ray absorptiometry,and the serum levels of bone alkaline phosphatase(NBAP),osteocalcin(OC),matrix metalloproteinase-2(MMP-2)and calcitonin(CT)were detected by ELISA method.The primary symptom scores of intestinal function,serum diamine oxidase(DAO)and D-lactic acid(D-Lac)levels were compared between the two groups before and after treatment,and the clinical efficacy of the two groups was evaluated.Results The total effective rate was 85.9%(55/64)in the observation group,which was higher than 71.9%(46/64)in the control group(P<0.05).After treatment,BMD were increased(P<0.05),and serum bone metabolism indexes were improved in the two groups(P<0.05);the BMD and serum bone metabolism indexes in the observation group were better than those in the control group(P<0.05).After treatment,the primary symptom scores of intestinal function,serum DAO and D-Lac levels in the observation group were decreased(P<0.05),and the indexes in the observation group were lower than those in the control group(P<0.05).Conclusion The adjuvant therapy of Wentong acupuncture could increase BMD,improve bone metabolism and regulate intestinal function in elderly patients of primary osteoporosis with intestinal dysfunction.