文献类型：期刊文献

英文题名：New perspectives on the roles of circular RNAs in osteoarthritis development and progression (Review)

作者：Cao, Guoding[1,2];Pei, Yuqi[3];Li, Peng[2,3];Liu, Peng[2];Deng, Yapeng[2,4];Gao, Yu[2,5];Liu, Jun[6,7];Li, Xusheng[2,8]

第一作者：Cao, Guoding

通信作者：Liu, J[1];Li, XS[2]

机构：[1]Gansu Med Coll, Affiliated Hosp, Dept Orthoped, Pingliang 744000, Gansu, Peoples R China;[2]940th Hosp Joint Logist Support Force Chinese Peop, Dept Orthoped, Lanzhou 730050, Gansu, Peoples R China;[3]Gansu Univ Tradit Chinese Med, Lanzhou 730000, Gansu, Peoples R China;[4]Lanzhou Univ, Sch Med, Lanzhou 730000, Gansu, Peoples R China;[5]Ningxia Med Univ, Sch Med, Yinchuan 750000, Ningxia, Peoples R China;[6]Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Orthoped, Xian 710061, Shanxi, Peoples R China;[7]Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Orthoped, 157 Xiwu Rd, Xian 710061, Shanxi, Peoples R China;[8]940th Hosp Joint Logist Support Force Chinese Peop, Dept Orthoped, 333 Binhe South Rd, Lanzhou 730050, Gansu, Peoples R China

第一机构：Gansu Med Coll, Affiliated Hosp, Dept Orthoped, Pingliang 744000, Gansu, Peoples R China

通信机构：[1]corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Orthoped, 157 Xiwu Rd, Xian 710061, Shanxi, Peoples R China;[2]corresponding author), 940th Hosp Joint Logist Support Force Chinese Peop, Dept Orthoped, 333 Binhe South Rd, Lanzhou 730050, Gansu, Peoples R China.

年份：2021

卷号：22

期号：6

外文期刊名：EXPERIMENTAL AND THERAPEUTIC MEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000878934900001)】；

语种：英文

外文关键词：osteoarthritis; chondrocyte; extracellular matrix; circular RNA

摘要：Osteoarthritis (OA) is a common disease of the elderly, posing a major personal and socioeconomic burden. OA is characterized by painful degeneration of articular cartilage, and its prevention, diagnosis and treatment remain problematic. Circular RNAs (circRNAs) constitute a large family of non-coding RNAs that are widely distributed, stable, conserved and tissue-specific. circRNAs have been found to be closely associated with OA development and progression, and they may serve as targets for disease prevention and treatment. The aim of the present article was to review the roles of circRNAs in OA and discuss possible treatment strategies.