文献类型：期刊文献

英文题名：Injectable hydroethanolic physical gels based on Codonopsis pilosula polysaccharide for sustained anticancer drug delivery

作者：Zhao, Tingting[1];Dong, Shuqing[2,3];Shao, Shijun[2,3];Lu, Guodi[1];Hou, Jia[1];Yang, Fude[1]

第一作者：赵婷婷

通信作者：Yang, FD[1];Shao, SJ[2];Shao, SJ[3]

机构：[1]Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]Lanzhou Inst Chem Phys, Chinese Acad Sci, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China;[3]Lanzhou Inst Chem Phys, Chinese Acad Sci, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China;[2]corresponding author), Lanzhou Inst Chem Phys, Chinese Acad Sci, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China;[3]corresponding author), Lanzhou Inst Chem Phys, Chinese Acad Sci, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China.|[1073501e14fb35863569f]甘肃中医药大学药学院（西北中藏药协同创新中心办公室）;[10735]甘肃中医药大学;

年份：2023

卷号：230

外文期刊名：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000991151500001)】；

基金：This work was supported by the National Natural Science Foundation of China [No. 32061143035] , the National Key R & D Program Fund of the Ministry of Science and Technology [2018YFC1706305] , the Gansu Provincial Key Research & Development Program Project [No. 20YF8FA003] and the 2021 Gansu University industry support plan project [2021CYZC-40] .

语种：英文

外文关键词：Codonopsis pilosula polysaccharide; Hydroethanolic physical gels; Injectable and self-recovering

摘要：The development of biocompatible carriers based on hydroethanolic physical gels for effectively encapsulating and delivering hydrophobic drug molecules is of particular interest. In this paper, we reported a novel hydro-ethanolic physical gel based on Codonopsis pilosula polysaccharide (CPP) prepared from the roots of C. pilosula. The gelation behaviors of the graded CPP fractions in a water-ethanol solvent system were evaluated, and the physicochemical and mechanical properties of the CPP-based gel (CPP-G) were characterized. The results indi-cated that CPP-G had consisted of a random physically crosslinked network formed by hydrophobic association of CPP chains and exhibited good mechanical strength, higher shear-thinning sensitivity and rapid, highly efficient self-recovering characteristics, ensuring superior performance in constructing injectable and self -recovering drug-loaded gels. Hydrophobic paclitaxel (PTX) and hydrophilic doxorubicin (DOX) were used as representative drugs to investigate the encapsulation and in vitro release behaviors of CPP-G, which exhibited long-term sustained release properties. Additionally, the evaluation of drug activity in drug-loaded gels further revealed the synergistic effect of CPP-G with the selected drugs on tumor inhibition against 4T1 and MCF-7 breast cancer cell lines. This work evaluated the feasibility of using the natural polysaccharide CPP to construct hydroethanolic physical gels and the applicability of the injectable drug-loaded gels for hydrophobic drug delivery.