文献类型：期刊文献

英文题名：What Is the Optimal Timing of Transplantation of Neural Stem Cells in Spinal Cord Injury? A Systematic Review and Network Meta-Analysis Based on Animal Studies

作者：Shang, Zhizhong[1];Li, Dongliang[1];Chen, Jinlei[1];Wang, RuiRui[1];Wang, Mingchuan[1];Zhang, Baolin[1];Wang, Xin[1,2,3];Wanyan, Pingping[4,5]

第一作者：Shang, Zhizhong

通信作者：Wang, X[1];Wang, X[2];Wang, X[3];Wanyan, PP[4];Wanyan, PP[5]

机构：[1]Lanzhou Univ, Clin Med Sch 1, Lanzhou, Peoples R China;[2]Chengren Inst Tradit Chinese Med, Lanzhou, Peoples R China;[3]Naval Med Univ, Changzheng Hosp, Dept Spine, Shanghai, Peoples R China;[4]Gansu Univ Chinese Med, Basic Med Coll, Lanzhou, Peoples R China;[5]Second Hosp Lanzhou Univ, Dept Nephrol, Lanzhou, Peoples R China

第一机构：Lanzhou Univ, Clin Med Sch 1, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Clin Med Sch 1, Lanzhou, Peoples R China;[2]corresponding author), Chengren Inst Tradit Chinese Med, Lanzhou, Peoples R China;[3]corresponding author), Naval Med Univ, Changzheng Hosp, Dept Spine, Shanghai, Peoples R China;[4]corresponding author), Gansu Univ Chinese Med, Basic Med Coll, Lanzhou, Peoples R China;[5]corresponding author), Second Hosp Lanzhou Univ, Dept Nephrol, Lanzhou, Peoples R China.|[107351d2d02a88e1f325f]甘肃中医药大学基础医学院（敦煌医学研究所）;[10735]甘肃中医药大学;

年份：2022

卷号：13

外文期刊名：FRONTIERS IN IMMUNOLOGY

收录：;Scopus(收录号：2-s2.0-85127411370);WOS:【SCI-EXPANDED(收录号:WOS:000783578000001)】；

基金：This work was supported by the Gansu Natural Science Foundation (No. 21JR7RA362; 21JR7RA413) and The First Hospital of Lanzhou University Foundation (No. ldyyyn 2021-121).

语种：英文

外文关键词：neural stem cells; spinal cord injury; animal study; systematic review; network meta-analysis; transplantation timing

摘要：Objective: The optimal transplantation timing of neural stem cells in spinal cord injury is fully explored in animal studies to reduce the risk of transformation to clinical practice and to provide valuable reference for future animal studies and clinical research. Method: Seven electronic databases, namely, PubMed, Web of Science, Embase, Wanfang, Chinese Scientific Journal Database (CSJD-VIP), China Biomedical Literature Database (CBM), and China National Knowledge Infrastructure (CNKI), were searched. The studies were retrieved from inception to November 2021. Two researchers independently screened the literature, extracted data, and evaluated the methodological quality based on the inclusion criteria. Results and Discussion: Thirty-nine studies were incorporated into the final analyses. Based on the subgroup of animal models and transplantation dose, the results of network meta-analysis showed that the effect of transplantation in the subacute phase might be the best. However, the results of traditional meta-analysis were inconsistent. In the moderate-dose group of moderate spinal cord injury model and the low-dose group of severe spinal cord injury model, transplantation in the subacute phase did not significantly improve motor function. Given the lack of evidence for direct comparison between different transplantation phases, the indirectness of our network meta-analysis, and the low quality of evidence in current animal studies, our confidence in recommending cell transplantation in the subacute phase is limited. In the future, more high-quality, direct comparative studies are needed to explore this issue in depth.