文献类型：期刊文献

英文题名：Double-carrier drug delivery system based on polyurethane-polyvinyl alcohol/layered double hydroxide nanocomposite hydrogel

作者：Li, Xiuqi[1];Gong, Peiwei[2];Li, Yezhou[3];Yu, Jingfang[4];Wang, Fu[1];Li, Xiaoan[5];Fan, Zengjie[5];Wang, Zhaofeng[1]

第一作者：Li, Xiuqi

通信作者：Wang, F[1];Wang, ZF[1]

机构：[1]Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Gansu, Peoples R China;[2]Qufu Normal Univ, Dept Chem & Chem Engn, Key Lab Life Organ Anal, Qufu 273165, Shandong, Peoples R China;[3]Gansu Univ Chinese Med, Sch Informat Sci & Engn, Lanzhou 730000, Gansu, Peoples R China;[4]Univ Oxford, Dept Chem, Chem Res Lab, Oxford, England;[5]Lanzhou Univ, Sch Stomatol, Lanzhou 730000, Gansu, Peoples R China

第一机构：Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Solid Lubricat, Lanzhou 730000, Gansu, Peoples R China.

年份：2019

卷号：243

起止页码：1

外文期刊名：MATERIALS LETTERS

收录：;EI(收录号：20190706499867);Scopus(收录号：2-s2.0-85061340846);WOS:【SCI-EXPANDED(收录号:WOS:000460395500001)】；

基金：This work is supported by CAS Pioneer Hundred Talents Program, Natural Science Foundation of Gansu Province (18JR3RA384), National Natural Science Foundation of China (51805519 and 81571829), and grants from Gansu University of Chinese Medicine (2305137502 and ZQ2015-3).

语种：英文

外文关键词：Biomaterials; Nanocomposites; Structural

摘要：In this work, a biocompatible and stretchable double-carrier drug delivery system was developed for wound dressing application. Quinolone antibiotics enoxacin (ENO) was loaded into Mg-Al layered double hydroxide (LDH) first, and then the as-prepared LDH-ENO nanoparticles were incorporated into polyurethane-polyvinyl alcohol (PU-PVA) hydrogel to build a double-carrier drug delivery system. The results suggested that the introduction of the LDH-ENO nanoparticles into PU-PVA network significantly improved the mechanical properties and biocompatibility of PU-PVA hydrogel. The PU-PVA/LDH-ENO nanocomposite hydrogel, as a double-carrier, obviously delayed the release of the ENO molecules. It suggests that PU-PVA/LDH-ENO nanocomposite hydrogel should be a promising candidate for wound healing applications, especially for the healing of chronic wounds. (C) 2019 Elsevier B.V. All rights reserved.