文献类型：期刊文献

英文题名：The silent dialogue between cells: regulatory roles of non-coding RNAs in cardiovascular disease

作者：Zhang, Zhongwen[1];Yang, Yufei[1];Liu, Mengzhen[1];Zhang, Hang[2];Li, Zhaoyu[3];Zhang, Jingjing[4,5,6];Zhang, Haolong[2]

第一作者：张忠文

通信作者：Zhang, HL[1];Zhang, JJ[2];Zhang, JJ[3];Zhang, JJ[4]

机构：[1]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, Lanzhou, Gansu, Peoples R China;[4]Kunming Med Univ, Chinese Acad Med Sci, Fuwai Yunnan Hosp, Affiliated Cardiovasc Hosp, Kunming, Peoples R China;[5]Yunnan Prov Cardiovasc Clin Med Ctr, Kunming, Peoples R China;[6]Yunnan Prov Cardiovasc Clin Med Res Ctr, Kunming, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou, Gansu, Peoples R China;[2]corresponding author), Kunming Med Univ, Chinese Acad Med Sci, Fuwai Yunnan Hosp, Affiliated Cardiovasc Hosp, Kunming, Peoples R China;[3]corresponding author), Yunnan Prov Cardiovasc Clin Med Ctr, Kunming, Peoples R China;[4]corresponding author), Yunnan Prov Cardiovasc Clin Med Res Ctr, Kunming, Peoples R China.|[10735ccd4a8840d96ab71]甘肃中医药大学中医临床学院;[10735]甘肃中医药大学;

年份：2026

卷号：14

外文期刊名：FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001892479800001)】；

语种：英文

外文关键词：biomarkers; cardiovascular disease; individualized therapy; molecular regulation; non-coding RNA; precision medicine

摘要：Non-coding RNAs (ncRNAs) are involved in the occurrence, progression, and repair of cardiovascular disease By post-transcriptional regulation, epigenetic modification, cell-fate determination, and metabolic homeostasis-related pathways, microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) regulate the development of atherosclerosis heart failure and hypertension The stability in circulation and cell type-specific expression of these molecules have important implications for early disease detection, risk stratification, and prognostic prediction. The development of more sensitive detection techniques facilitates accurate quantification of ncRNAs in different sources including exosomes, plasma or tissues and promotes translational research. Interventions directed toward the regulation of ncRNAs, such as miRNA inhibition or replacement and modulation of lncRNAs and circRNAs are being developed. Despite existing challenges related to ncRNA delivery, specificity, and methodological standardization, ncRNAs represent promising molecular signatures for personalized medicine. Integrated use of multi-omics, clinical phenotypes and computational algorithms is anticipated to optimize an ncRNA-guided precision management pipeline from diagnosis to prediction and treatment.