文献类型：期刊文献

中文题名：层次分析法-熵权法结合正交试验优化龙葵素膏成型工艺

英文题名：Optimization of Solanine Ointment Formulation Process Using Analytic Hierarchy Process-Entropy Weight Method Combined with Orthogonal Test

作者：褚平铵[1];郝江峰[1];彭腾腾[1];石晓峰[2];谢兴文[3];李宁[1,3];宋鹏[3]

第一作者：褚平铵

机构：[1]甘肃中医药大学,甘肃兰州730000;[2]甘肃省医学科学研究院,甘肃兰州730050;[3]甘肃中医药大学附属医院,甘肃兰州730000

第一机构：甘肃中医药大学

年份：2025

卷号：53

期号：7

起止页码：25

中文期刊名：中医药学报

外文期刊名：Acta Chinese Medicine and Pharmacology

基金：国家自然科学基金地区科学基金项目(82060873);兰州市人才创新创业项目(2021-RC-88);甘肃省中医药管理局项目(GZK-2019-25)。

语种：中文

中文关键词：马铃薯;龙葵素;龙葵素膏;层次分析法-熵权法;成型工艺

外文关键词：Potato;Solanine;Solanine ointment;Analytic hierarchy process-entropy weight method;Formulation process

摘要：目的:优化龙葵素膏成型工艺。方法:采用乙醇-乙酸双溶剂法从马铃薯皮中提取龙葵素中主要成分α-茄碱后,使用高效液相色谱法对其进行含量测定;以黏度值和主观评价为指标综合评分,采用层次分析法-熵权法确定各评价指标的权重系数,通过单因素试验和正交试验分别考察凡士林、羊毛脂、蜂蜡的用量对龙葵素软膏品质的影响,优选最佳成型工艺参数。结果:高效液相色谱法测得马铃薯皮中α-茄碱的含量为14.81 mg·g^(-1);优选得到龙葵素膏油性基质的最佳配比为凡士林用量10 g,羊毛脂用量0.75 g,蜂蜡用量0.55 g。结论:龙葵素膏成型工艺合理可行,制得的成品均匀细腻,延展性、耐热耐寒性、稳定性均较好,可为龙葵素的开发及应用提供理论依据。
Objective:To optimize the formulation process of solanine ointment.Methods:The main componentα-solanine was extracted from potato peel using ethanol-acetic acid dual-solvent method,and its content was determined by high-performance liquid chromatography(HPLC).Taking viscosity value and subjective evaluation as indicators,a comprehensive score was calculated,and the weight coefficients of each evaluation index were determined using the analytic hierarchy process(AHP)-entropy weight method.Single-factor tests and orthogonal tests were conducted to investigate the effects of the amounts of vaseline,lanolin,and beeswax on the quality of solanine ointment,aiming to determine the optimal formulation parameters.Results:The HPLC results showed that the content ofα-solanine in potato peel was 14.81 mg·g^(-1).The optimal ratio of the oleaginous matrix for solanine ointment was determined as follows:vaseline 10 g,lanolin 0.75 g,and beeswax 0.55 g.Conclusion:The formulation process of solanine ointment is reasonable and feasible,producing a uniform and fine product with good spreadability,thermal/cold resistance,and stability,which provides a theoretical basis for the development and application of solanine.