文献类型：期刊文献

英文题名：Deciphering the Role of LncRNAs in Osteoarthritis: Inflammatory Pathways Unveiled

作者：Hu, Kangyi[1];Wen, Haonan[1];Song, Ting[1];Che, Zhixin[1];Song, Yongjia[1];Song, Min[1]

第一作者：Hu, Kangyi

通信作者：Song, YJ[1];Song, M[1]

机构：[1]Gansu Univ Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学中医临床学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Clin Coll Tradit Chinese Med, Lanzhou 730000, Peoples R China.|[10735ccd4a8840d96ab71]甘肃中医药大学中医临床学院;[10735]甘肃中医药大学;

年份：2024

卷号：17

起止页码：6563

外文期刊名：JOURNAL OF INFLAMMATION RESEARCH

收录：;Scopus(收录号：2-s2.0-85205227809);WOS:【SCI-EXPANDED(收录号:WOS:001318462300001)】；

基金：Funding The work was supported by Gansu University of Chinese Medicine to introduce a talent research start-up fund (2024YJRC-09) and The 2024 Gansu Basic Research Program-Natural Science Funds-Youth Science and Technology Fund (24JRRA567) .

语种：英文

外文关键词：osteoarthritis; LncRNA; inflammation; chondrocytes; pro-inflammatory factors

摘要：Long non-coding RNA (LncRNA), with transcripts over 200 nucleotides in length, play critical roles in numerous biological functions and have emerged as significant players in the pathogenesis of osteoarthritis (OA), an inflammatory condition traditionally viewed as a degenerative joint disease. This review comprehensively examines the influence of LncRNA on the inflammatory processes driving OA progression, focusing on their role in regulating gene expression, cellular activities, and inflammatory pathways. Notably, LncRNAs such as MALAT1, H19, and HOTAIR are upregulated in OA and exacerbate the inflammatory milieu by modulating key signaling pathways like NF-kappa B, TGF-beta/SMAD, and Wnt/beta-catenin. Conversely, LncRNA like MEG3 and GAS5, which are downregulated in OA, show potential in dampening inflammatory responses and protecting against cartilage degradation by influencing miRNA interactions and cytokine production. By enhancing our understanding of LncRNA' roles in OA inflammation, we can better leverage them as potential biomarkers for the disease and develop innovative therapeutic strategies for OA management. This paper aims to delineate the mechanisms by which LncRNA influence inflammatory responses in OA and propose them as novel targets for therapeutic intervention.