文献类型：期刊文献

英文题名：Research progress on the synergistic effect and its mechanisms of antidepressants and antibiotics against resistant pathogens

作者：Ding, Lihong[1];Chen, Xia[1];Lv, Yanli[1];Peng, Qianyu[1];Wang, Ruirui[1];Yang, Bo[1];Wei, Lianhua[2]

第一作者：Ding, Lihong

通信作者：Wei, LH[1]

机构：[1]Gansu Univ Chinese Med, Sch Publ Hlth, Lanzhou 730000, Peoples R China;[2]Gansu Prov Hosp, Dept Clin Lab, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学公共卫生学院

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Clin Lab, Lanzhou 730000, Peoples R China.

年份：2025

卷号：207

期号：7

外文期刊名：ARCHIVES OF MICROBIOLOGY

收录：;Scopus(收录号：2-s2.0-105006924047);WOS:【SCI-EXPANDED(收录号:WOS:001498850300003)】；

基金：This work was supported by the Research Projects of Gansu Provincial Hospital (grant number 24GSSYD-3), and Gansu Provincial Clinical Research Center for Laboratory Medicine (21JR7RA676).

语种：英文

外文关键词：Antidepressants; Antibiotics; Antibiotic adjuvant; Drug-resistant pathogens; Synergy mechanisms

摘要：Antimicrobial resistance (AMR) poses a critical global health challenge, driving the urgent need for innovative therapeutic strategies. Antidepressants, traditionally used for major depressive disorders (MDD), have recently attracted attention in non-antibiotic research due to their diverse pharmacological properties, including antimicrobial, antifungal, antiviral, anticancer, antiparasitic, and anti-inflammatory activities. Selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) demonstrated synergistic antimicrobial effects with reduced minimum inhibitory concentrations (MIC) when used in combination with conventional antibiotics, enhancing efficacy against drug-resistant pathogens. Mechanisms underlying this synergy include inhibition of bacterial efflux pumps and disruption of membrane integrity. Despite these promising findings, in vivo studies evaluating antidepressant-antibiotic synergy remain scarce, underscoring the need for further mechanistic and translational research to overcome challenges in clinical application. Overall, antidepressants show significant potential as adjuvants to antibiotics against resistant bacteria, making them promising candidates for combination therapy.