文献类型：期刊文献

中文题名：脊柱结核兔模型的建立及研究进展

英文题名：Establishment and research progress of rabbit model of spinal tuberculosis

作者：杨军[1];邓强[2];彭冉东[3];李军杰[4];王雨榕[5];杨海云[1];杜健强[1]

第一作者：杨军

机构：[1]甘肃中医药大学研究生院,兰州730000;[2]甘肃省中医院医务处,兰州730050;[3]甘肃省中医院骨髓炎科,兰州730050;[4]甘肃省中医院脊柱骨二科,兰州730050;[5]甘肃省中医院脊柱骨三科,兰州730050

第一机构：甘肃中医药大学党委研究生工作部、研究生院

年份：2023

卷号：45

期号：5

起止页码：520

中文期刊名：中国防痨杂志

外文期刊名：Chinese Journal of Antituberculosis

收录：CSTPCD;;CSCD:【CSCD_E2023_2024】；

基金：2021年甘肃省财政转移支付地方项目/中西医结合防治耐药菌研究(20210140305);基于中医临床研究基地优势病种的中医临床疗效评价能力提升(20210200111);脊柱患者术后切口感染相关危险因素及远期预后的回顾分析研究(21JR1RA057)。

语种：中文

中文关键词：结核,脊柱;疾病模型,动物;兔;综述文献(主题)

外文关键词：Tuberculosis,spinal;Disease models,animal;Rabbits;Review literature as topic

摘要：结核病由结核分枝杆菌侵袭人体器官引起。脊柱结核占肺外结核的50%,已成为严重威胁人类健康的骨科疾病,其发病机制尚未完全明确,可使用的抗结核药物和治疗方案有限。动物模型作为研究疾病发病机制及治疗药物的有力工具备受关注。新西兰兔因其腰椎解剖结构与人类相似,骨结核病变表现可以复现人类结核病病理表现,以及构建脊柱结核模型操作方便等特点,广泛用于脊柱结核动物模型实验研究。笔者综述了脊柱结核兔模型构建方法及其在结核病发病机制、抗结核新药研发及局部载药研究中的应用价值,为脊柱结核相关基础研究中兔模型的建立及应用提供参考。
Tuberculosis is caused by Mycobacterium tuberculosis by invading human organs.Spinal tuberculosis accounts for 50%of extra-pulmonary tuberculosis and has become a serious orthopedic disease that threatens human health.The pathogenesis of spinal tuberculosis has not yet been fully understood,and the available anti-tuberculosis drugs and treatment options are limited.As a powerful tool for studying the pathogenesis of diseases and therapeutic drugs,animal models have received considerable attention.New Zealand rabbits are widely used as animal models in the experimental study of spinal tuberculosis because of their similar anatomical structure of lumbar vertebrae to humans,the manifestation of bone tuberculosis can reproduce the pathological manifestations of human tuberculosis,and the convenient operation of constructing spinal tuberculosis models.This article reviewed the construction method of spinal tuberculosis rabbit models and the application value in the pathogenesis of tuberculosis,the development of new anti-tuberculosis drugs and local drug loading research,to provide reference for the establishment and application of rabbit models in basic research related to spinal tuberculosis.