文献类型：期刊文献

中文题名：miRNA介导p38MAPK信号通路调控成骨细胞在糖尿病性骨质疏松症中的作用

英文题名：Roles of osteoblasts regulated by p38MAPK signaling pathway mediated by miRNA in diabetes osteoporosis

作者：马欢欢[1];王晓晖[2];王晶[1];王亚萍[1];马桃梅[1];韩世杰[1]

第一作者：马欢欢

机构：[1]甘肃中医药大学,兰州730030;[2]甘肃省中医院糖尿病科,兰州730050

第一机构：甘肃中医药大学

年份：2023

卷号：16

期号：1

起止页码：80

中文期刊名：中华骨质疏松和骨矿盐疾病杂志

外文期刊名：Chinese Journal Of Osteoporosis And Bone Mineral Research

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：国家中医优势专科建设项目(甘卫中医函〔2023〕63号);甘肃省科技重点研发计划(21YF5FA022);兰州市人才创新创业项目(2021-RC-118)。

语种：中文

中文关键词：微小RNA;p38MAPK信号通路;成骨细胞;糖尿病性骨质疏松症

外文关键词：microRNA;p38MAPK signal pathway;osteoblasts;diabetes osteoporosis

摘要：糖尿病性骨质疏松症(diabetes osteoporosis,DOP)是糖尿病在骨骼系统的慢性并发症,为糖尿病患者致残、致死的主要原因之一,目前临床上对DOP的治疗方法有限,主要以预防及延缓病程发展为主,使得探寻有效治疗的关键靶点成为当前的重中之重。研究发现微小RNA(microRNA,miRNA)是骨重塑的重要调节剂之一,可通过介导不同信号通路参与骨代谢的调节,如高糖诱导下成骨细胞中高表达的p38MAPK信号通路,因此通过探寻miRNA与p38MAPK信号通路的关系可为筛选治疗DOP有效靶点提供新的思路。本文从p38MAPK信号通路对成骨细胞的调控、miRNA对成骨细胞的调控作用、miRNA介导p38MAPK信号通路调控成骨细胞及治疗DOP的策略等进行综述,为临床治疗DOP提供理论依据。
Diabetes osteoporosis(DOP)is a chronic comorbidity of diabetes in the skeletal system and one of the main causes of disability and death in patients with diabetes,At present,the clinical treatment of DOP is limited,mainly focusing on preventing and delaying the development of the disease.Studies have found that microRNA(miRNA)is one of the important regulators of bone remodeling,which can participate in the regulation of bone metabolism by mediating different signal pathways,such as p38MAPK signal pathway highly expressed in osteoblasts induced by high glucose.Therefore,exploring the relationship between miRNA and p38MAPK signal pathway can provide a new idea for screening effective targets for the treatment of DOP.This article summarized the regulation of p38MAPK signal pathway on osteoblasts,the regulation of miRNA on osteoblasts,the regulation of p38MAPK signal pathway mediated by miRNA on osteoblasts and the strategy of treating DOP,so as to provide a basis for treatment of this disease.