文献类型：期刊文献

中文题名：基于“异病同治”与知识图谱挖掘神经退行性疾病的中医药证治规律

英文题名：Exploring the Rules of TCM Patterns and Treatment for Neurodegenerative Disease Based on"Same Therapy for Different Diseases"and Knowledge Graph

作者：杨焕[1,2];郭敏[3,4];陈江凤[1];魏赛雪[1];李晓东[3,4];李娟[1,5]

第一作者：杨焕

机构：[1]甘肃中医药大学药学院,甘肃兰州730010;[2]陕西国际商贸学院药学院,陕西西安712046;[3]甘肃省中医院,甘肃兰州730050;[4]甘肃省中医药研究院,甘肃兰州730050;[5]甘肃省人民医院康复医学科,甘肃兰州730000

第一机构：甘肃中医药大学药学院（西北中藏药协同创新中心办公室）

年份：2025

卷号：38

期号：9

起止页码：97

中文期刊名：西部中医药

外文期刊名：Western Journal of Traditional Chinese Medicine

基金：甘肃省联合科研基金一般项目(25JRRA1221)。

语种：中文

中文关键词：神经退行性疾病;证治规律;知识图谱;数据挖掘;异病同治

外文关键词：neurodegenerative disease;the rule of dialectical treatment;knowledge graph;data mining;same therapy for different diseases

摘要：目的 :采用文献计量学和数据挖掘技术探究中医药治疗神经退行性疾病(neurodegenerative disease,NDDs)的研究热点和用药特点。方法:通过中国知网(CNKI)、万方、维普和WOS数据库检索中医药治疗NDDs的研究前沿及临床研究的病例文献,对关键词进行逐年关注度和聚类分析;对中药、疾病和证候进行频数统计、关联规则和聚类分析,探讨中医药治疗NDDs的用药规律。结果:关键词逐年关注度和聚类分析结果显示中医药治疗NDDs以阿尔茨海默病(Alzheimer's disease,AD)和帕金森病(Parkinson's disease,PD)占据2/3,而其他疾病如亨廷顿病(Huntington's disease,HD)、肌萎缩性侧索硬化(amyotrophic lateral sclerosis,ALS)、脊髓性肌萎缩症(spinal muscular atrophy,SMA)、多系统萎缩(multiple system atrophy,MSA)、脊髓小脑共济失调(spinocerebellar ataxia,SCA)、多发性硬化(multiple sclerosis,MS)、创伤性脑损伤(traumatic brain injury,TBI)、癫痫(epilepsy,EP)、原发性Tau蛋白病研究较少或几乎无文献报道,且以单体成分研究居多;数据挖掘结果显示NDDs共同病位证候要素为肝、肾,共同病性证候要素为血瘀;共同中药为茯苓、甘草、熟地黄、当归、白术,化裁为八珍汤加减方,能发挥气血同调、滋养肝肾的功效;共同中药功效以补虚、活血化瘀、化痰止咳平喘、利水渗湿为主。结论:在中医辩证论治中,NDDS的病位要素为肝、肾,病性证候要素为血瘀,治疗方法以补肝肾、补虚、活血化瘀为主,符合“异病同治”治疗原则。
Objective:To explore the research hotspots and medication characteristics of TCM therapy for NDDs using bibliometrics and data mining technology.Methods:Medical records and literature regarding clinical studies and frontier research on TCM therapy for NDDs were retrieved from CNKI,Wanfang,VIP and WOS databases,to conduct annual attention and cluster analysis of the keywords;frequency statistics,association rules and cluster analysis of herbs,diseases and syndromes were carried out to survey the medication rules of TCM therapy of NDDs.Results:The results of annual attention and cluster analysis of the keywords demonstrated that AD and PD accounted for two-thirds in TCM treatment for NDDs,while little or no literature has been reported on other diseases including HD,ALS,SMA,MSA,SCA and MS,TBI,EP and primary tauopathy,mostly regarding the studies on the ingredients;the results of data mining revealed that syndrome elements with common pathological location of NDDs were liver and kidney,the syndrome elements with common nature was blood stasis;the common herbs were Fuling[Poria cocos(Schw.)Wol],Gancao(Glycyrrhizae radix et rhizoma),Shudihuang(Rehmanniae radix praeparata),Danggui(Angelicae sinensis radix)and Baizhu(Atractylodes macrocephala Koidz.),and the prescription was modified Bazhen decoction,exerting the effects of regulating Qi and blood,nourishing liver and kidney;the clinical efficacy of the common herbs was to tonify the deficiency,promote blood circulation and resolve blood stagnation,resolve phlegm,stop cough and relieve asthma,clear damp and promote diuresis mainly.Conclusion:In syndrome differentiation and treatment of NDDs,the elements of location of NDDs are liver and kidney,the nature is blood stasis,therapeutic method is to tonify liver and kidney,tonify the deficiency,promote blood circulation and resolve blood stagnation,conforming to therapeutic principles of"same therapy for different diseases".