文献类型：期刊文献

英文题名：Pressure and Fluorescence Dual Signal Readout CuO-NiO/C Heterojunction Nanofibers-Based Nanoplatform for Imaging and Detection of Target Cancer Cells in Blood

作者：Wang, Zhiyi[1,2];Hai, Jun[1,2];Li, Tianrong[1,2];Ding, Erli[1,2];He, Jianxin[3];Wang, Baodui[1,2]

第一作者：Wang, Zhiyi

通信作者：Wang, BD[1];Wang, BD[2]

机构：[1]Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China;[2]Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China;[3]Gansu Univ Chinese Med, Basic Med Sch, Lanzhou 730000, Gansu, Peoples R China

第一机构：Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China;[2]corresponding author), Lanzhou Univ, Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Gansu, Peoples R China.

年份：2018

卷号：6

期号：8

起止页码：9921

外文期刊名：ACS SUSTAINABLE CHEMISTRY & ENGINEERING

收录：;EI(收录号：20182605357205);Scopus(收录号：2-s2.0-85048764425);WOS:【SCI-EXPANDED(收录号:WOS:000441475500046)】；

基金：The work was supported by the National Natural Science Foundation of China (Grants 21671088, 21431002, and 21501080) and the Fundamental Research Funds for the Central Universities (Grant lzujbky-2018-it03). We wish to thank the Electron Microscopy Centre of Lanzhou University for the microscopy and microanalysis of our specimens.

语种：英文

外文关键词：Pressure; Biosensing; Fluorescence imaging; Multifunctional nanoplatform; Whole blood; Cancer diagnosis

摘要：The development of multifunctional nanoplatform, which integrates biosensing and imaging diagnosis, for accurate identification of cancer cells in blood or other bodily fluids is critical for early cancer diagnosis and treatment. Herein, by using a facile single spinneret electrospinning technique followed by thermal treatment, CuO-NiO/C heterojunction nanofiber was synthesized. The resultant CuO-NiO/C nanofibers exhibited excellent catalytic activity toward ammonia borane (AB) hydrolysis, producing a marked pressure increase in a closed reaction vessel. Moreover, the resultant nanofibers showed highly efficient catalytic activity for reduction of rhodamine 6G (Rh6G, fluorescent molecule), accompanied by the fluorescence quenching. On the basis of these findings, a novel sensing platform utilizing folic-acid (FA) conjugated CuO-NiO/C nanofibers as an artificial enzyme and recognition element for fluorescence imaging and pressure based (pressure meter) detection of folate receptor (FR)-positive cancer cells was developed. The detection limit is as low as 50 cells/mL. What's more, the clinical applicability of the sensor was also proven to be suitable for the sensing cancer cells in whole blood. The most important advantage of the synthesized nanofibers based-probe is the combination of pressure meter and fluorescence imaging to specifically see and sensitively count the cancer cells, paving a new way in early liver cancer diagnosis.