文献类型：期刊文献

英文题名：Strategies to enhance the therapeutic efficacy of anti-PD-1 antibody, anti-PD-L1 antibody and anti-CTLA-4 antibody in cancer therapy

作者：Su, Xin[1,2];Li, Jian[1,2];Xu, Xiao[1,2];Ye, Youbao[1,2];Wang, Cailiu[1,2];Pang, Guanglong[1,2];Liu, Wenxiu[1,2];Liu, Ang[1,2];Zhao, Changchun[1,2];Hao, Xiangyong[2]

第一作者：苏祥;Su, Xin

通信作者：Hao, XY[1]

机构：[1]Gansu Univ Chinese Med, Clin Med Coll 1, Lanzhou 730000, Peoples R China;[2]Gansu Prov Hosp, Dept Gen Surg, 204 Donggang West Rd, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Gen Surg, 204 Donggang West Rd, Lanzhou 730000, Peoples R China.

年份：2024

卷号：22

期号：1

外文期刊名：JOURNAL OF TRANSLATIONAL MEDICINE

收录：;Scopus(收录号：2-s2.0-85200920811);WOS:【SCI-EXPANDED(收录号:WOS:001287641000001)】；

基金：Not applicable.DAS:Not applicable.

语种：英文

外文关键词：Immune checkpoint inhibitors; Immunotherapy; Combination therapy; Tumor microenvironment; Cancer therapy

摘要：Although immune checkpoint inhibitors (anti-PD-1 antibody, anti-PD-L1 antibody, and anti-CTLA-4 antibody) have displayed considerable success in the treatment of malignant tumors, the therapeutic effect is still unsatisfactory for a portion of patients. Therefore, it is imperative to develop strategies to enhance the effect of these ICIs. Increasing evidence strongly suggests that the key to this issue is to transform the tumor immune microenvironment from a state of no or low immune infiltration to a state of high immune infiltration and enhance the tumor cell-killing effect of T cells. Therefore, some combination strategies have been proposed and this review appraise a summary of 39 strategies aiming at enhancing the effectiveness of ICIs, which comprise combining 10 clinical approaches and 29 foundational research strategies. Moreover, this review improves the comprehensive understanding of combination therapy with ICIs and inspires novel ideas for tumor immunotherapy.