文献类型：期刊文献

英文题名：Clinical and humoral immune response characterization of SARS-CoV-2 Omicron BA.2.38 infection in pediatric patients

作者：Liu, Yu[1,2];Zhao, Liunuobei[2,3];Wang, Li[4];Li, Yuxia[5];Wang, Longde[5];Yu, Bo[4];Hu, Di[6];Weng, Heng[7];Guo, Jianwen[7,8];Yang, Jinghua[9];Yang, Jing[1,2];Yu, Xiaobo[1,2,3]

第一作者：Liu, Yu

通信作者：Yang, J[1];Yu, XB[1];Yang, J[2];Yu, XB[2];Yu, XB[3];Guo, JW[4];Guo, JW[5];Yang, JH[6]

机构：[1]Anhui Med Univ, Sch Basic Med Sci, Hefei, Anhui, Peoples R China;[2]Beijing Inst Life Co Ltd, State Key Lab Prote, Beijing Proteome Res Ctr, Natl Ctr Protein Sci Beijing PHOENIX Ctr, Beijing 102206, Peoples R China;[3]Hebei Univ, Coll Chem & Environm Sci, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding 071002, Peoples R China;[4]2 Peoples Hosp Lanzhou, Dept Lab, Lanzhou, Gansu, Peoples R China;[5]Gansu Univ Chinese Med, Affiliated Hosp, Dept Pediat, Lanzhou, Gansu, Peoples R China;[6]ProteomicsEra Med Co Ltd, Beijing 102206, Peoples R China;[7]Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Dampness Syndrome Chinese Med, Guangzhou, Peoples R China;[8]Guangzhou Univ Chinese Med, Affiliated Hosp, Dept Neurol, Guangzhou, Peoples R China;[9]Guangdong Prov Hosp Chinese Med, Ying Lvs Sch Studio Chinese Med, Dept Pediat, Xiaorong Luos Renowned Expert Inheritance Studio C, Guangzhou, Guangdong, Peoples R China

第一机构：Anhui Med Univ, Sch Basic Med Sci, Hefei, Anhui, Peoples R China

通信机构：[1]corresponding author), Anhui Med Univ, Sch Basic Med Sci, Hefei, Anhui, Peoples R China;[2]corresponding author), Beijing Inst Life Co Ltd, State Key Lab Prote, Beijing Proteome Res Ctr, Natl Ctr Protein Sci Beijing PHOENIX Ctr, Beijing 102206, Peoples R China;[3]corresponding author), Hebei Univ, Coll Chem & Environm Sci, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding 071002, Peoples R China;[4]corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Dampness Syndrome Chinese Med, Guangzhou, Peoples R China;[5]corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp, Dept Neurol, Guangzhou, Peoples R China;[6]corresponding author), Guangdong Prov Hosp Chinese Med, Ying Lvs Sch Studio Chinese Med, Dept Pediat, Xiaorong Luos Renowned Expert Inheritance Studio C, Guangzhou, Guangdong, Peoples R China.

年份：2023

卷号：9

期号：7

外文期刊名：HELIYON

收录：;Scopus(收录号：2-s2.0-85164748765);WOS:【SCI-EXPANDED(收录号:WOS:001044045500001)】；

基金：This work was supported by the Beijing Municipal Natural Science Foundation (M21003 and M23010) , National Key R & D Program of China (2022YFE0210400, 2021YFA1301604, 2020YFE0202200) , State Key Laboratory of Proteomics (SKLP-O202007) , Guangdong Province Science and Technology Planning Project (2020B1111100006) , Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine. (No: ZYYCXTD-C-202204) . We thank Dr. Brianne Petritis for her critical review and editing of this manuscript.

语种：英文

外文关键词：COVID-19; SARS-CoV-2; Variant of concern; Pediatric patients; Antibody response; Proteomics

摘要：Omicron variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a health concern for both unvaccinated and vaccinated individuals against coronavirus disease 2019 (COVID-19). To date, the humoral immune response following vaccination and natural infection remains uncharacterized in children ages 17 years and younger. To address this concern, we performed clinical and immunological analyses of IgM and IgG antibody responses to SARS-CoV-2 Omicron BA.2.38 infection in 64 pediatric patients. COVID-19 symptom severity decreased with age in pediatric patients, from 70.8% (17/24) in patients 0-2 years of age to 50% (6/12) and 50% (14/28) in patients 3-5 years and 6-17 years of age, respectively. Furthermore, fewer patients experienced symptoms when vaccinated with the CoronaVac or BBIBP-CorV vaccine (50%, 13/ 26) than unvaccinated patients (71%, 22/31). Using a protein array, we found that the Omicron BA.2.38 infection induced antibody responses to other Omicron variants (Omicron BA.1-BA.5), which increased with vaccination. Notably, non-Omicron and Omicron variants showed distinct serotypes. Altogether, our results provide insight into the clinical and immunological characteristics of pediatric patients with COVID-19 Omicron BA.2.38 who have and have not been vaccinated against COVID-19. These data may help develop more effective diagnostic tests and vaccines in the future.