文献类型：期刊文献

中文题名：诱导近视巩膜重塑的分子免疫学机制研究

英文题名：Molecular immunological mechanisms of inducing myopicscleral remodeling

作者：周扬[1,2];吕洋[2]

第一作者：周扬

机构：[1]甘肃中医药大学第一临床医学院,兰州730000;[2]中国人民解放军联勤保障部队第九四○医院眼科,兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2025

卷号：48

期号：3

起止页码：313

中文期刊名：国际免疫学杂志

外文期刊名：International Journal of Immunology

基金：国家自然科学基金(82000926);甘肃省卫生健康委员基金(GSWSKY2022-05);甘肃省自然科学基金(24JRRA003);中国人民解放军联勤保障部队第九四○医院院基金(2021yxky033,2023YXKY011,2023YXKY033);军队课题(24BJZ41,2024-G2-4);兰州市科技计划项目(2024-9-126);中央高校基本科研专项(31920250055)。

语种：中文

中文关键词：近视;巩膜重塑;细胞外基质

外文关键词：Myopia;Scleral remodeling;Extracellular matrix

摘要：近视已成为全球范围内视力损害的主要原因之一,我国儿童青少年高度近视患病率持续上升,并呈现向低龄化发展的趋势。巩膜明显变薄、眼轴过度伸长是近视进展的特征表现之一。巩膜重塑是细胞外基质成分改变的结果,受多种细胞因子和信号转导通路调控。目前,抑制或减缓巩膜重塑成为从根本上阻止或延缓近视发生及进展的新热点。文章综述了可能参与诱导巩膜重塑的分子免疫学机制,以期为寻找近视防控靶点及研究方向提供依据。
Myopia,as the main cause of visual impairment in children worldwide,has led to a continuous increase in the incidence of high myopia among children and adolescents in China,with a trend towards younger age groups.Significant thinning of the sclera and excessive elongation of the eyeball axis are characteristic manifestations of myopia progression.Scleral remodeling is the result of changes in extracellular matrix components and is regulated by various cytokines and signal transduction pathways.At present,controlling scleral remodeling has become a new hotspot to fundamentally prevent or delay the development of myopia.This review summarizes the molecular immunological mechanisms that may be involved in inducing scleral remodeling,in order to provide some reference and assistance for finding targets and research directions for myopia prevention and control.