文献类型：期刊文献

英文题名：Prognostic potential of miR-144 in various cancers: A meta-analysis

作者：Jia, Chong-Yang[1];He, Yan[1];Wu, Shi-Nan[2,3];He, Yan-Ting[4,5,6];Wang, Ying[7]

第一作者：Jia, Chong-Yang

通信作者：He, YT[1];He, YT[2]

机构：[1]Second Hosp Lanzhou, Dept Gen Surg, Lanzhou, Peoples R China;[2]Nanchang Univ, Dept Clin Med, Clin Med Coll 1, Nanchang, Peoples R China;[3]Xiamen Univ, Eye Inst, Sch Med, Xiamen, Fujian, Peoples R China;[4]Nanchang Univ, Sch Pharm, Nanchang, Peoples R China;[5]Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu, Peoples R China;[6]Collaborat Innovat Ctr Biotherapy, Chengdu, Peoples R China;[7]Gansu Univ Chinese Med, Dept Clin Lab, Affiliated Hosp, Lanzhou, Peoples R China

第一机构：Second Hosp Lanzhou, Dept Gen Surg, Lanzhou, Peoples R China

通信机构：[1]corresponding author), Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China;[2]corresponding author), Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China.

年份：2022

卷号：101

期号：46

起止页码：E31728

外文期刊名：MEDICINE

收录：;Scopus(收录号：2-s2.0-85142401804);WOS:【SCI-EXPANDED(收录号:WOS:000890207100088)】；

语种：英文

外文关键词：cancer; meta-analysis; microrNA-144; prognosis

摘要：Background: MicrorNA-144 (MiR-144) has been shown to be an attractive prognostic tumor biomarker and play a fundamental role in various cancers, However, the conclusion was inconsistency. The aim of this study was to identify the prognostic role of miR-144 in cancers. Methods: Relevant studies were searched in PubMed, EMBASE and Web of Science up to April 20, 2022. Hazard ratios (HR), odds ratio (OR) and 95% confidence intervals were pooled from the selected studies. Results: A total of 15 articles involving 1846 participants fulfilled the inclusion criteria. The results revealed that low miR-144 expression was significantly associated with favorable overall survival (HR: 0.68, 95% confidence interval [CI]: 0.53-0.88) in various cancers. Low miR-144 expression had better predictive value in patients with urinary system cancer (HR: 0.48, 95% CI: 0.35-0.64). In addition, low miR-144 expression was associated with tumor diameter (big vs small) (OR: 1.69, 95% CI: 1.08-2.75), tumor stage (III-IV vs I-II) (OR: 2.52, 95% CI: 3.76-8.14) and invasion depth (T3 + T4 vs T2 + T1) (OR: 3.24, 95% CI: 1.72-4.89). Conclusion: miR-144 may serve as a prognostic biomarker in cancers.