文献类型：期刊文献

英文题名：Bioactive components and clinical potential of Astragalus species

作者：Li, Shuo[1,2];Hu, Xunpeng[1,2,3];Liu, Fen[3];Hu, Weiming[3,4]

第一作者：李硕

通信作者：Liu, F[1];Hu, WM[1];Hu, WM[2]

机构：[1]Gansu Univ Chinese Med, Gansu Phamaceut Ind Innovat Res Inst, Key Lab Qual & Stand TCM Gansu Prov, Lanzhou, Peoples R China;[2]Gansu Univ Chinese Med, Coll Pharm, Lanzhou, Peoples R China;[3]Jiangxi Prov & Chinese Acad Sci, Jiangxi Prov Key Lab Plant Germplasm Resources Inn, Lushan Bot Garden, Jiujiang, Peoples R China;[4]Jiangxi Acad Forestry, Nanchang, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Jiangxi Prov & Chinese Acad Sci, Jiangxi Prov Key Lab Plant Germplasm Resources Inn, Lushan Bot Garden, Jiujiang, Peoples R China;[2]corresponding author), Jiangxi Acad Forestry, Nanchang, Peoples R China.

年份：2025

卷号：16

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-105007010378);WOS:【SCI-EXPANDED(收录号:WOS:001498718900001)】；

基金：The author(s) declare that financial support was received for the research and/or publication of this article. This research was funded by the Gansu Provincial Department of Education, Industrial Support Program Project (2025CYZC-050 to SL), the Gansu Natural Science Foundation Project (23JRRA1716 to SL), Jiangxi Provincial Introduced Intelligence Program (20212BCJ25025 to WH), Jiujiang City "double hundred double thousand" talent project to WH, and National Natural Science Foundation of China (32160099 to WH).

语种：英文

外文关键词：bioactive molecules; Astragalus; pharmacological action; mechanism of action; medicine and food homology (MFH)

摘要：Astragalus L., the world's largest vascular plant genus, has been used medicinally and as food for centuries, especially in traditional Chinese medicine It is widely applied in immune modulation, antioxidant therapy, anti-inflammatory treatments, and antitumor applications. Recent studies show that Astragalus species is rich in bioactive compounds, such as polysaccharides, flavonoids, saponins, alkaloids, and simple phenolics, which demonstrate significant pharmacological effects, including anti-inflammatory, antioxidant, immunomodulatory, and antitumor properties, along with potential benefits for Alzheimer's disease and diabetes. This review synthesizes 140 references to analyze 51 newly identified flavonoids, 31 triterpenoid saponins, and 19 alkaloids in Astragalus (2020-2025), focusing on their chemical structures and bioactivities. It also examines Astragalus species in medicine and food homology (MFH) and how processing methods affect its efficacy. Furthermore, the mechanisms behind its anti-inflammatory, antioxidant, immune-boosting, antitumor, neuroprotective, and hypoglycemic effects are discussed. Future studies should prioritize large-scale clinical trials to confirm Astragalus's efficacy and safety, explore combination therapies, and improve sustainable resource utilization to expand its medical and food applications. Keywords: Bioactive molecules, Astragalus, Pharmacological action, Mechanism of action, Medicine and food homology (MFH).