文献类型：期刊文献

中文题名：轮状病毒疫苗的研究现状

英文题名：Progress in studies on rotavirus vaccine

作者：王明雯[1];李丹地[2]

第一作者：王明雯

机构：[1]甘肃中医药大学公共卫生学院,兰州730000;[2]中国疾病预防控制中心病毒病预防控制所,北京102206

第一机构：甘肃中医药大学公共卫生学院

年份：2021

卷号：35

期号：3

起止页码：312

中文期刊名：中华实验和临床病毒学杂志

外文期刊名：Chinese Journal of Experimental and Clinical Virology

收录：CSTPCD;;Scopus;CSCD:【CSCD_E2021_2022】；PubMed;

基金：国家重点研发项目(2018YFC1200602);国家自然科学基金(21934005,81601813)。

语种：中文

中文关键词：轮状病毒;腹泻;疫苗;

外文关键词：Rotavirus;Diarrhea;Vaccine

摘要：轮状病毒是全球婴幼儿重症腹泻的最主要病原,世界卫生组织统计每年大约有18.5万例患儿因轮状病毒死亡,相关死亡主要发生在亚洲和非洲的低收入国家,即使在卫生条件较好的地区也普遍发生轮状病毒感染,表明轮状病毒具有较高的传播能力。目前尚无针对轮状病毒腹泻的特效治疗药物,只能对症治疗。因此,安全有效的疫苗对降低轮状病毒腹泻的发病率和死亡率具有非常重要的意义。世界卫生组织也建议口服轮状病毒疫苗应该纳入到所有国家的计划免疫中。目前,我国的口服轮状病毒疫苗LLR在2001年于我国上市,多数国家市场上使用的疫苗为Rotarix(RV1)和Rotateq(RV5),疫苗的使用对预防因轮状病毒感染导致腹泻入院有良好的效果,接种疫苗来预防轮状病毒疾病具有非常好的成本效益。本文对轮状病毒疫苗现况进行综述,以期为轮状病毒病的防控提供科学依据。
Rotavirus is the most important pathogen of severe diarrhea in infants and young children in the world.According to the World Health Organization,about 185000 children die from rotavirus each year.The related deaths mainly occur in low-income countries in Asia and Africa.Rotavirus infections are common even in areas with better sanitary conditions,indicating that rotavirus has a high transmission capacity.At present,there is no specific treatment for rotavirus diarrhea,only symptomatic treatment is available.Therefore,safe and effective vaccines are of great significance in reducing the incidence and mortality of rotavirus diarrhea.The World Health Organization also recommends that oral rotavirus vaccines should be included in the immunization program of all countries.At present,China’s oral rotavirus vaccine LLR has been on the market in China since 2001.The vaccines available on the market in most countries are Rotarix(RV1)and Rotateq(RV5).The vaccine is useful for preventing diarrhea caused by rotavirus infection.The vaccination to prevent rotavirus disease is very cost-effective.This article reviews the current situation of rotavirus vaccines in order to provide a scientific evidences for the prevention and control of rotavirus.