文献类型：期刊文献

英文题名：LncRNA Linc00173 may be a potential prognostic biomarker in human solid tumors: a meta-analysis and bioinformatics analysis

作者：Zhou, Cong[1];Huang, Yalong[1];Tian, Yong[2];Zhang, Bangxing[2];Yang, Xiaojun[3,4,5,6]

第一作者：周晨

通信作者：Yang, XJ[1];Yang, XJ[2];Yang, XJ[3];Yang, XJ[4]

机构：[1]Gansu Univ Tradit Chinese Med, Clin Med Coll 1, Lanzhou 730000, Gansu, Peoples R China;[2]Ningxia Med Univ, Sch Clin Med, Yinchuan 750000, Peoples R China;[3]Gansu Prov Hosp, Dept Gen Surg 2, Lanzhou 73000, Peoples R China;[4]Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Peoples R China;[5]Gansu Prov Hosp, Gansu Key Lab Mol Diagnost & Precis Med Surg Oncol, Lanzhou 730000, Peoples R China;[6]Gansu Prov Hosp, Gansu Res Ctr Prevent & Control Project Digest Onc, Lanzhou 730000, Peoples R China

第一机构：甘肃中医药大学

通信机构：[1]corresponding author), Gansu Prov Hosp, Dept Gen Surg 2, Lanzhou 73000, Peoples R China;[2]corresponding author), Lanzhou Univ, Clin Med Coll 1, Lanzhou 730000, Peoples R China;[3]corresponding author), Gansu Prov Hosp, Gansu Key Lab Mol Diagnost & Precis Med Surg Oncol, Lanzhou 730000, Peoples R China;[4]corresponding author), Gansu Prov Hosp, Gansu Res Ctr Prevent & Control Project Digest Onc, Lanzhou 730000, Peoples R China.

年份：2023

卷号：478

期号：11

起止页码：2553

外文期刊名：MOLECULAR AND CELLULAR BIOCHEMISTRY

收录：;Scopus(收录号：2-s2.0-85149478117);WOS:【SCI-EXPANDED(收录号:WOS:000952927700003)】；

基金：This work was supported by Ph.D. postgraduate tutor training project, No. 22GSSYA-3; National Health Commission Key Laboratory for Diagnosis and Treatment of Gastrointestinal Tumors 2022 Master/Doctor/Postdoctoral Fund Project, No. NHCDP2022001; Gansu Province innovation base and talent Project Funding, No. 20JR10RA433; Key R & D projects of provincial science and technology plan in Gansu province, No.21YF5WA027; Gansu Province Health Industry Research Plan, No. GSWSKY2020-45. And the fundings can support the publication of this manuscript.

语种：英文

外文关键词：LncRNA; Linc00173; Solid tumors; Meta;analysis; Bioinformatics analysis

摘要：Despite advances in diagnostic techniques and treatments, cancer remains one of the leading causes of death worldwide.Therefore, finding new biomarkers and therapeutic targets is crucial for improving the diagnosis and treatment of human cancer.LncRNA Linc00173 is a newly identified tumor marker, and in this study, we aimed to explore the relationship between Linc00173 and clinicopathological features and patient prognosis. By using The Cochrane Library, EMbase, Web of Science, PubMed, OVID, we conducted a complete and thorough literature search from its inception to November 10, 2022.Meta-analysis was performed using Stata SE16.0 software. Nine studies involving 1102 patients were included.Meta-analysis showed that the overexpression of Linc00173 was significantly associated with poorer OS (HR = 1.76,95%CI:1.36-2.26, P < 0.001) and shorter DFS (HR = 1.89, 95%CI:1.49-2.40,P < 0.001),and was significantly associated with gender (male) (OR = 1.31,95% CI:1.01-1.69, P = 0.042), tumor size (large) (OR = 1.34,95% CI:1.01-1.78, P = 0.045), and lymph node metastasis (positive) (OR = 1.72,95% CI:1.03-2.88, P = 0.038). Overexpression of Linc00173 is associated with poor prognosis in cancer patients and is a potential prognostic biomarker and therapeutic target.