文献类型：期刊文献

英文题名：Altered Effective Connectivity Within the Frontoparietal Network in Alzheimer's Disease and Its Modulation by Acupuncture: A Resting-State fMRI Study

作者：Wei, Yu-Ting[1,2];Li, Li[1];Xie, Wen-Ting[1];Wang, Yan[1];Zhao, Ya-Ru[1];Zhang, Ren-Zhen[1];Ma, Ling[1];Yan, Xing-Ke[1,2]

第一作者：魏玉桃;Wei, Yu-Ting

通信作者：Yan, XK[1]

机构：[1]Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, 35 Dingxi East Rd, Lanzhou, Gansu, Peoples R China;[2]Res Ctr Tradit Chinese Med, Lanzhou, Gansu, Peoples R China

第一机构：甘肃中医药大学针灸推拿学院

通信机构：[1]corresponding author), Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, 35 Dingxi East Rd, Lanzhou, Gansu, Peoples R China.|[10735db5df93766a96e5b]甘肃中医药大学针灸推拿学院;[10735]甘肃中医药大学;

年份：2026

卷号：22

外文期刊名：NEUROPSYCHIATRIC DISEASE AND TREATMENT

收录：;Scopus(收录号：2-s2.0-105041869186);WOS:【SCI-EXPANDED(收录号:WOS:001794821600001)】；

基金：This research was funded by the Open Project of the Research Center of Traditional Chinese Medicine, Gansu Province (No. zyzx-2024-zx09, zyzx-2024-zx03) , Gansu Province University Teacher Innovation Fund Project (No.2024A-082) , Scientific Research Start-up Fund Project for Introduced Talents of Gansu University of Chinese Medicine (No. 2024YJRC-06) .

语种：英文

外文关键词：Alzheimer's disease; acupuncture; resting-state functional magnetic resonance imaging; frontoparietal network; effective connectivity

摘要：Purpose: Alzheimer's disease (AD) is increasingly prevalent, yet how acupuncture modulates cognitive brain networks remains unclear. We used resting-state fMRI (rs-fMRI) to examine whether acupuncture prescription regulates effective connectivity within the frontoparietal network (FPN) in AD. Patients and Methods: Sixty AD patients were randomized to donepezil alone (drug group) or acupuncture plus donepezil (acupuncture group) for 6 weeks (n=30/group). Seven healthy controls were scanned once. Global cognition was assessed with MoCA-B. Independent component analysis identified the FPN, and Granger causality analysis quantified directed effective connectivity before and after treatment. Results: Both interventions improved MoCA-B (P<0.05), with larger gains in the acupuncture group (P<0.05). Relative to controls, AD showed FPN disruption with compensatory reorganization. Decreased connectivity was observed from the left middle temporal gyrus (MTG) to the right inferior parietal lobule (IPL), and from the left median cingulate/paracingulate gyri (P<0.05). Increased connectivity emerged from the right IPL and left cingulate/paracingulate to the left MTG, and from the right IPL to the left medial frontal gyrus (orbital part) (P<0.05). The right IPL and left MTG were core FPN nodes. Post-treatment, the drug group showed reduced right IPL-*left orbital medial frontal connectivity, whereas the acupuncture group showed reduced right IPL-*left MTG connectivity (P<0.05). Between-group comparisons indicated acupuncture-specific modulation of right insula-*left MTG and left precuneus-*left MTG connectivity (P<0.05). Conclusion: Acupuncture combined with donepezil provides superior cognitive benefits and selectively reshapes directed FPN interactions, supporting a network-level mechanism involving frontal-parietal-temporal integration.