文献类型：期刊文献

中文题名：内皮祖细胞在再生医学中的应用

英文题名：Application of endothelial progenitor cell in regenerative medicine

作者：李欣[1,2,3];蒋如如(综述)[1,2,3];哈小琴(审校)[1,2]

第一作者：李欣

机构：[1]甘肃中医药大学临床医学院,甘肃兰州730030;[2]解放军联勤保障部队第九四〇医院检验科,甘肃兰州730050;[3]甘肃省干细胞与基因药物重点实验室,甘肃兰州730050

第一机构：甘肃中医药大学临床医学院

年份：2020

卷号：33

期号：4

起止页码：449

中文期刊名：中国生物制品学杂志

外文期刊名：Chinese Journal of Biologicals

收录：CSTPCD;;Scopus;CSCD:【CSCD_E2019_2020】；

语种：中文

中文关键词：内皮祖细胞;再生医学;细胞治疗;基因治疗

外文关键词：Endothelial progenitor cell(EPC);Regenerative medicine;Cell therapy;Gene therapy

摘要：随着血管内皮祖细胞(endothelial progenitor cell,EPC)研究的深入,EPC的分离、体外培养、鉴定及在血管相关性疾病(如缺血性疾病)和各种肿瘤发生发展中的作用及功能已成为新的研究热点。EPC具有分化功能,增殖能力极强,体外扩增培养速度快,主要存在于外周血、脐血、骨髓中,且容易获取,是干细胞移植疗法理想的种子细胞来源。目前,EPC在治疗心脑血管、肢体缺血性疾病等方面的研究十分活跃,并初步取得了肯定的成果。本文主要就EPC在再生医学中的细胞治疗及基因治疗上的应用作一综述。
With the further study of endothelial progenitor cell(EPC),the isolation,in vitro culture and identification of EPC and their roles in the pathogenesis and progress of vascular diseases such as ischemic diseases as well as various tumors have become the new focus in the field of research. EPC have a differential function and strong proliferation ability and were propagated rapidly in vitro,which mainly exist in peripheral blood,umbilical cord blood and born marrow and is an ideal source of cell seed for stem cell transplantation therapy. At present,EPC were researched actively in the field of therapy of cardiovascular and cerebrovascular diseases and limb ischemic diseases,in which the definite achievements have been obtained. This paper describes the application of EPC in cell therapy and gene therapy in regenerative medicine.