文献类型：期刊文献

英文题名：Remodeling of non-coding RNA regulatory networks: Decoding the pathological mechanisms and new therapeutic paradigms of cardiovascular diseases

作者：Zhang, Wangzheqi[2];Duan, Lei[1];Wang, Changli[2];Liao, Yan[2];Zhao, Rui[3];Li, Zhaoyu[4];Zhang, Haoling[5];Wang, Zengwu[6];Zhang, Jing-jing[7,8,9]

第一作者：Zhang, Wangzheqi

通信作者：Zhang, HL[1];Wang, ZW[2];Zhang, JJ[3];Zhang, JJ[4];Zhang, JJ[5]

机构：[1]Northwest Univ, Xian Aerosp Hosp, Dept Anesthesiol, Xian, Shaanxi Provinc, Peoples R China;[2]Naval Med Univ, Changhai Hosp, Fac Anesthesiol, Shanghai 200433, Peoples R China;[3]Gansu Univ Chinese Med, 35 Dingxi East Rd, Lanzhou 730000, Gansu Province, Peoples R China;[4]Gansu Univ Chinese Med, Coll Acupuncture Moxibust & Tuina, 35 Dingxi East Rd, Lanzhou 730000, Gansu Province, Peoples R China;[5]Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, George Town 13200, Malaysia;[6]Peking Union Med Coll & Chinese Acad Med Sci, Div Prevent & Community Hlth, Natl Clin Res Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis,Fuwai Hosp, Beijing 102308, Peoples R China;[7]Kunming Med Univ, Fuwai Yunnan Hosp, Chinese Acad Med Sci, Affiliated Cardiovasc Hosp, 528 Shahe North Rd, Kunming 650000, Peoples R China;[8]Yunnan Prov Cardiovasc Clin Med Ctr, 528 Shahe North Rd, Kunming 650000, Peoples R China;[9]Yunnan Prov Cardiovasc Clin Med Res Ctr, 528 Shahe North Rd, Kunming 650000, Peoples R China

第一机构：Northwest Univ, Xian Aerosp Hosp, Dept Anesthesiol, Xian, Shaanxi Provinc, Peoples R China

通信机构：[1]corresponding author), Univ Sains Malaysia, Adv Med & Dent Inst, Dept Biomed Sci, George Town 13200, Malaysia;[2]corresponding author), Peking Union Med Coll & Chinese Acad Med Sci, Div Prevent & Community Hlth, Natl Clin Res Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis,Fuwai Hosp, Beijing 102308, Peoples R China;[3]corresponding author), Kunming Med Univ, Fuwai Yunnan Hosp, Chinese Acad Med Sci, Affiliated Cardiovasc Hosp, 528 Shahe North Rd, Kunming 650000, Peoples R China;[4]corresponding author), Yunnan Prov Cardiovasc Clin Med Ctr, 528 Shahe North Rd, Kunming 650000, Peoples R China;[5]corresponding author), Yunnan Prov Cardiovasc Clin Med Res Ctr, 528 Shahe North Rd, Kunming 650000, Peoples R China.

年份：2026

卷号：56

起止页码：131

外文期刊名：PHYSICS OF LIFE REVIEWS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001653930100001)】；

基金：This research was supported by grants from the Fund Project of National Natural Science Foundation of China, No. 82302421, Science and Technology Department of Yunnan Province-Kunming Medical University, Kunming Medical joint special project-surface project, China, No. 202401AY070001-164; and Yunnan Provincial Department of Science and Technology Science and Technology Plan Project-Major Science and Technology Special Projects, China, No. 202405AJ310003; and the Yunnan Pan Xiangbin Expert Workstation under the Yunnan Provincial Project for Scientific and Technological Talents and Platforms Project, No. 202305AF150069.

语种：英文

外文关键词：Non-coding RNAs (ncRNAs); Cardiovascular Diseases (CVDs); Regulatory Mechanisms; Biomarkers; Therapeutic Strategies; Clinical Translation; ceRNA dynamics; Biophysical constraints; Spatial transcriptomics; Exosomal transport

摘要：The essential role of non-coding RNAs (ncRNAs) in cardiovascular disease (CVD) research instigates a shift from empirical studies to those based on molecular mechanisms, targeted interventions, and personalized health management in the world of precision medicine. This review systematically summarizes the expression profiles and multilayered regulatory mechanisms of various ncRNAs such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and small nucleolar RNAs (snoRNAs) in a variety of cardiovascular diseases (CVDs) ranging from congenital heart disease to atherosclerosis (AS), cardiomyopathies, heart failure (HF), and arrhythmias. The central roles of key pathological pathways like epigenetic changes, competing endogenous RNA (ceRNA), inflammation and cell fate determination will be highlighted. From a diagnostic point of view, ncRNAs have good potentials as early-stage biomarkers, in applications such as exosomal liquid biopsy, disease classification, and prognosis. Emerging technologies, notably locked nucleic acid (LNA) oligonucleotides, adeno-associated virus serotype 9 (AAV9)-based delivery systems and engineered exosomes, are unlocking new avenues for intervention on the therapeutic front. These developments, coupled with drug repurposing strategies and tissue-specific delivery platforms, can make ncRNA-targeted therapies more specific and controllable. At the same time, interdisciplinary innovations, like single-cell multi-omics, spatial transcriptomics, CRISPR-dCas9 systems, and deep learning assist clinical translation greatly. However, the real-world application of ncRNA-based therapies is constrained by many challenges like low delivery efficiency, functional redundancy, and microenvironmental dependence. Future directions must aim to create integrative platforms that can dynamically identify and modulate ncRNA functions to link mechanistic studies to personalized therapies and subsequently expedite clinical translation of ncRNA discoveries. In this sense, three cross-scale principles-network topology and ceRNA competition dynamics; spatiotemporal gradients modeled by exosome transport and tissue microenvironments; and energetic/stoichiometric constraints like Dicer processing capacity and miRNA-target ratios-provide an analytical framework that appears recurrently across diverse CVD phenotypes and tighten the mechanistic unity of this review.