文献类型：期刊文献

中文题名：丹参酮胶囊对多囊卵巢综合征大鼠糖脂代谢及性激素的影响

英文题名：Effects of Tanshinone Capsules on Glucose and Lipid Metabolism and Serum Sex Hormone in PCOS Rats

作者：虎亚光[1];岳嘉[2];李金娟[2];刘建鸿[2];陈丽[2];张书楠[2]

第一作者：虎亚光

机构：[1]甘肃省妇幼保健院药事管理科,兰州730050;[2]甘肃中医药大学公共卫生学院,兰州730000

第一机构：甘肃省妇幼保健院药事管理科,兰州730050

年份：2016

卷号：27

期号：19

起止页码：2632

中文期刊名：中国药房

外文期刊名：China Pharmacy

收录：CSTPCD;;北大核心:【北大核心2014】；

基金：兰州市科技计划项目(No.2014-1-18)

语种：中文

中文关键词：丹参酮胶囊;多囊卵巢综合征;大鼠;糖脂代谢;性激素

外文关键词：Tanshinone capsules; Polycystic ovarian syndrome; Rats; Glucose and lipid metabolism; Sex hormone

摘要：目的:研究丹参酮胶囊对多囊卵巢综合征(PCOS)大鼠糖脂代谢及血清性激素水平的影响。方法:选取90只雌性SD大鼠,随机分为正常组(蒸馏水)、模型组(蒸馏水)、阳性对照组(二甲双胍200 mg/kg)和丹参酮胶囊低、中、高剂量组(30、60、90 mg/kg),每组15只。除正常组外其余各组大鼠复制PCOS模型,建模后各组大鼠ig相应药物,每天1次,连续给药28 d。比较干预前、干预28 d后各组大鼠的排卵率,检测干预后各组大鼠体质量、脂肪湿质量、空腹胰岛素(FINS)、空腹血糖(FPG)、葡萄糖曲线下面积(AUC)、胰岛素敏感指数(HOMA-IR、ISI)和血清中促卵泡生成素(FSH)、促黄体生成素(LH)、睾酮(T)变化。结果:与正常组比较,模型组大鼠停止排卵,体质量、脂肪湿质量、FINS、FPG、葡萄糖AUC、HOMA-IR、FSH、LH、T均明显升高,ISI明显降低(P<0.05)。与模型组比较,阳性对照组和丹参酮胶囊各剂量组大鼠干预后排卵率明显升高,体质量(丹参酮胶囊低剂量组除外)、脂肪湿质量(丹参酮胶囊低剂量组除外)、FINS、FPG、葡萄糖AUC、HOMA-IR、FSH、LH、T均明显降低,ISI明显升高(P<0.05),其中丹参酮胶囊高剂量组和阳性对照组效果最明显。结论:丹参酮胶囊能调节PCOS大鼠的糖脂代谢和血清性激素分泌紊乱。
OBJECTIVE：To study the effects of Tanshinone capsules on glucose and lipid metabolism and serum sex hormone level in rats with polycystic ovary syndrome（PCOS）.METHODS：90 female SD rats were randomly divided into normal group（distilled water）,model group（distilled water）,positive control group（metformin 200 mg/kg）and Tanshinone capsules lowdose,medium-dose and high-dose groups（30,60,90 mg/kg）,with 15 rats in each group.Those groups were induced PCOS model except for normal group;after modeling,those groups were given relevant medicine intragastrically for consecutive 28 d,once a day.The ovulation rate was compared before intervention and 28 d after intervention.Body weight,fat wet weight,fasting insulin（FINS）,fasting blood-glucose（FPG）,AUC of glucose,HOMA-IR,ISI,serum levels of FSH,LH and T were detected.RESULTS：Compared with normal group,anovulation,body weight,fat wet weight,FINS,FPG,AUC of glucose,HOMA-IR,FSH,LH and T were all increased significantly in model group,while ISI decreased significantly（P〈0.05）.Compared with model group,ovulation rate and ISI of positive control group and Tanshinone capsules groups were increased significantly after intervention,while body weight（except for Tanshinone capsules low-dose group）,fat wet weight（except for Tanshinone capsules low-dose group）,FINS,FPG,AUC of glucose,HOMA-IR,FSH,LH and T were all decreased significantly（P〈0.05）,especially in Tanshinone capsules high-dose group and positive control group.CONCLUSIONS：Tanshinone capsules can regulate glucose and lipid metabolism and serum sex hormone secretion disorder in PCOS rats.