文献类型：期刊文献

中文题名：纳米MIL-101-NH_(2)(Fe)的合成及其对阿糖胞苷的负载释放研究

英文题名：Study on the Synthesis of Nano MIL-101-NH_(2)(Fe)and Its Load Release to Cytarabine

作者：王莉[1];游亚[2];吴来弟[2];刘立翔[2];段国建[2]

第一作者：王莉

机构：[1]贵阳学院理学院,贵州贵阳550005;[2]甘肃中医药大学药学院,甘肃兰州730000

第一机构：贵阳学院理学院,贵州贵阳550005

年份：2024

卷号：19

期号：4

起止页码：21

中文期刊名：贵阳学院学报(自然科学版)

外文期刊名：Journal of Guiyang University:Natural Sciences

基金：2024年甘肃省高校大学生就业创业提升工程项目(项目编号:202402)。

语种：中文

中文关键词：铁基MOFs;阿糖胞苷;吸附/解吸附;药物负载

外文关键词：Iron based MOFs;Cytarabine;Adsorption/desorption;Drug load

摘要：在我国恶性肿瘤发病率和死亡数持续上升的背景下,开发有效的治疗方法越来越被重视。其中,能够将药物分子精准递送到肿瘤部位并实现控制释放,是有效的治疗方法之一。基于此,合成了铁基MOFs材料,通过SEM、FT-IR和TGA等方法对MIL-101-NH_(2)(Fe)进行了分析。结果显示,MOFs材料的颗粒小于200 nm,能够有效结合阿糖胞苷,且热稳定性较好。通过优化吸附和解吸附条件,吸附量可以达到110 mg/g,解吸附率可以达到85%。
Under the background that the incidence and death of malignant tumor continue to rise in our country,more and more attention has been paid to developing effective treatment methods.It can accurately deliver drug molecules to the tumor site and achieve controlled release,which is one of the effective treatment methods.In this paper,iron-based MOFs material was synthesized,and MIL-101-NH_(2)(Fe)was analyzed by SEM,FT-IR and TGA.The results showed that the particles of MOFs material were smaller than 200 nm,which could effectively bind cytarabine and had good thermal stability.By optimizing the a4dsorption and desorption conditions,the adsorption capacity can reach 110 mg/g and the desorption rate can reach 85%.