文献类型：期刊文献

英文题名：Robust positive association between serum urate and the risk of chronic obstructive pulmonary disease: hospital-based cohort and Mendelian randomisation study

作者：Rao, Boqi[1];Xie, Dongming[2];Deng, Yibin[3,4];Ye, Junyi[2];Zeng, Xiaobin[2];Lin, Ao[2];Chen, Jinbin[5];Huang, Dongsheng[6];Xie, Chenli[7,8];Chen, Cuiyi[9];Luo, Yixuan[10];Lu, Xiaoxiao[11];Wang, Xinhua[12];Lu, Jiachun[2]

第一作者：Rao, Boqi

通信作者：Lu, JC[1]

机构：[1]Guangzhou Med Univ, Affiliated Hosp 2, Inst Publ Hlth, Emergency Dept,State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China;[2]Guangzhou Med Univ, Affiliated Hosp 1, Inst Chem Carcinogenesis, Sch Publ Hlth,Key Lab Adv Interdisciplinary Studie, Guangzhou, Guangdong, Peoples R China;[3]Youjiang Med Univ Nationalities, Afliated Hosp, Ctr Med Lab Sci, Baise, Guangxi, Peoples R China;[4]Key Lab Res Clin Mol Diag High Incidence Dis Weste, Baise, Guangxi, Peoples R China;[5]Guangzhou Med Univ, KingMed Sch Lab Med, Guangzhou, Guangdong, Peoples R China;[6]Shenzhen Longhua Dist Cent Hosp, Dept Resp & Crit Care Med, Shenzhen, Guangdong, Peoples R China;[7]Binhaiwan Cent Hosp Dongguan, Dept Resp & Crit Care Med, Dongguan, Guangdong, Peoples R China;[8]Dongguan Key Lab Precis, Dongguan, Guangdong, Peoples R China;[9]Songshan Lake Cent Hosp Dongguan, Dept Resp & Crit Care Med, Dongguan, Guangdong, Peoples R China;[10]Guangzhou Panyu Dist Cent Hosp, Guangzhou, Guangdong, Peoples R China;[11]Ludwig Maximilian Univ Munich, Dept English & Amer Studies, Fac Languages & Literatures, Munich, Germany;[12]Gansu Univ Chinese Med, Inst Basic Med, Lanzhou, Gansu, Peoples R China

第一机构：Guangzhou Med Univ, Affiliated Hosp 2, Inst Publ Hlth, Emergency Dept,State Key Lab Resp Dis, Guangzhou, Guangdong, Peoples R China

通信机构：[1]corresponding author), Guangzhou Med Univ, Affiliated Hosp 1, Inst Chem Carcinogenesis, Sch Publ Hlth,Key Lab Adv Interdisciplinary Studie, Guangzhou, Guangdong, Peoples R China.

年份：2024

卷号：11

期号：1

外文期刊名：BMJ OPEN RESPIRATORY RESEARCH

收录：;Scopus(收录号：2-s2.0-85187745515);WOS:【SCI-EXPANDED(收录号:WOS:001186500600001)】；

基金：This study was supported by the National Natural Science Foundation of China (82373678, 82173609 (JL)), Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (2017BT01S155 (JL)), Natural Science Foundation of Guangdong Province (2023A1515011627 (CX)), and Dongguan Science and Technology of Social Development Program (20221800905212 (CX)).

语种：英文

外文关键词：COPD epidemiology; Clinical Epidemiology

摘要：Background Chronic obstructive pulmonary disease (COPD) and hyperuricaemia are both characterised by systemic inflammation. Preventing chronic diseases among the population with common metabolic abnormality is an effective strategy. However, the association of hyperuricaemia with the higher incidence and risk of COPD remains controversial. Therefore, replicated researches in populations with distinct characteristics or demographics are compellingly warranted. Methods This cohort study adopted a design of ambispective hospital-based cohort. We used propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) to minimise the effects of potential confounding factors. A Cox regression model and restricted cubic spline (RCS) model were applied further to assess the effect of serum urate on the risk of developing COPD. Finally, we conducted a two-sample Mendelian randomisation (MR) analysis to explore evidence of causal association. Results There is a higher incidence in the population with hyperuricaemia compared with the population with normal serum urate (22.29/1000 person-years vs 8.89/1000 person-years, p=0.009). This result is robust after performing PSM (p=0.013) and IPTW (p<0.001). The Cox model confirms that hyperuricaemia is associated with higher risk of developing COPD (adjusted HR=3.35 and 95% CI=1.61 to 6.96). Moreover, RCS shows that the risk of developing COPD rapidly increases with the concentration of serum urate when it is higher than the reference (420 mol/L). Finally, in MR analysis, the inverse variance weighted method evidences that a significant causal effect of serum urate on COPD (OR=1.153, 95% CI=1.034 to 1.289) is likely to be true. The finding of MR is robust in the repeated analysis using different methods and sensitivity analysis. Conclusions Our study provides convincing evidence suggesting a robust positive association between serum urate and the risk of developing COPD, and indicates that the population with hyperuricaemia is at high risk of COPD in the Chinese population who seek medical advice or treatment in the hospital.