文献类型：期刊文献

英文题名：IL-6 and miR-1271 expression levels in elderly and young gastric cancer patients and correlation analysis with prognosis

作者：Liu, Shixiong[1];Zhou, Yun[1];Zhao, Li[2];Wang, Jing[1];Ji, Rui[3];Wang, Yiqing[1];Wu, Jiyin[1];Yan, Xiang[1]

第一作者：Liu, Shixiong

通信作者：Zhou, Y[1]

机构：[1]Lanzhou Univ, Hosp 1, Dept Geriatr 2, 418 Guazhou Rd, Lanzhou 730000, Gansu, Peoples R China;[2]Gansu Univ Chinese Med, Affiliated Hosp, Dept Ultrasound, Lanzhou 730020, Gansu, Peoples R China;[3]Lanzhou Univ, Hosp 1, Dept Gastroenterol, Lanzhou 730000, Gansu, Peoples R China

第一机构：Lanzhou Univ, Hosp 1, Dept Geriatr 2, 418 Guazhou Rd, Lanzhou 730000, Gansu, Peoples R China

通信机构：[1]corresponding author), Lanzhou Univ, Hosp 1, Dept Geriatr 2, 418 Guazhou Rd, Lanzhou 730000, Gansu, Peoples R China.

年份：2019

卷号：17

期号：6

起止页码：5419

外文期刊名：ONCOLOGY LETTERS

收录：;Scopus(收录号：2-s2.0-85065758250);WOS:【SCI-EXPANDED(收录号:WOS:000471330400082)】；

语种：英文

外文关键词：IL-6; miR-1271; elderly gastric cancer; young gastric cancer; prognosis

摘要：Differences in inflammatory factors IL-6 and miR-1271 expression levels between elderly and young gastric cancer patients were investigated. A retrospective analysis of 146 cases of gastric cancer tissue and normal fresh tissue specimens diagnosed in The First Hospital of Lanzhou University from January 2013 to January 2015, was performed. Patients aged 60 years were the elderly group (76 cases), and patients 40 years were the youth group (70 cases). RT-qPCR was used to detect the relative expression levels of IL-6 and miR-1271, and Kaplan-Meier for a postoperative 3-year survival analysis of young and elderly gastric cancer patients. The expression level of IL-6 and miR-1271 was significantly higher in young gastric cancer tissues than that in elderly gastric cancer tissues (P<0.001). The expression levels of IL-6 and miR-1271 were correlated with age, tumor size, lymph node metastasis, distant metastasis, clinical stage and differentiation degree of gastric cancer patients (P<0.05). The 3-year overall survival rate of patients with a low expression of IL-6 and miR-1271 was better than that of patients with a high expression in young and elderly gastric cancer (P<0.05). IL-6 was highly expressed but miR-1271 expression was low in gastric cancer tissues. The 3-year overall survival rate of patients with the low expression of IL-6 was better than that of patients with the high expression in young and elderly gastric cancer. The high expression of miR-1271 was better than that of patients with the low expression in young and elderly gastric cancer. Findings of the present study provide data support for the clinical evaluation of differences between young and elderly gastric cancer and their prognosis.