文献类型：期刊文献

中文题名：miR-146a介导TLR4/NF-κB信号通路延缓骨关节炎的作用及机制

英文题名：The effect and mechanism of miR-146a mediating TLR4/NF-κB signaling pathway in osteoarthritis

作者：刘建军[1];李元贞[1];王多贤[1];陈欣[1,2];齐伟[2];韩宪富[2];谢兴文[1,2]

第一作者：刘建军

机构：[1]甘肃中医药大学附属医院,甘肃兰州730000;[2]甘肃中医药大学,甘肃兰州730000

第一机构：甘肃中医药大学第二附属医院

年份：2023

卷号：29

期号：10

起止页码：1523

中文期刊名：中国骨质疏松杂志

外文期刊名：Chinese Journal of Osteoporosis

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2023_2024】；

基金：甘肃省卫生健康行业科研项目(GSWSKY-2021-009);兰州市城关区科技计划项目(2020-2-2-7);甘肃中医药大学附属医院院内创新基金(gzfy-2020-24);甘肃省科技计划资助(20JR5RA129);兰州市科技发展指导性计划项目(2022-20-91);甘肃省青年科技基金计划(20JR10RA345)。

语种：中文

中文关键词：骨关节炎;miR-146a;TLR4/NF-κB信号通路;研究进展

外文关键词：osteoarthritis;miR-146a;TLR4/NF-κB signaling pathway;research progress

摘要：骨关节炎(osteoarthritis,OA)作为慢性低度炎症性疾病,对它的研究一直是重点和难点,因此如何延缓OA的进展成为最主要的问题。miR-146a作为维持软骨稳态的关键调节因子,其表达的变化对软骨退变和炎症具有调节作用。Toll样受体4(toll-like receptor 4,TLR4)/核因子-κB(nuclear Factor-κB,NF-κB)信号通路通过调节免疫炎症反应,维持软骨代谢稳态。虽然miR-146a介导TLR4/NF-κB信号通路延缓OA已有研究,但是具体作用机制仍然不完善。本研究通过miR-146a介导TLR4/NF-κB信号通路对炎症及软骨细退变方面的综述,为OA的治疗提供理论依据和潜在分子靶标。
Osteoarthritis(OA)is a chronic low-grade inflammatory disease.It has always been the focus and difficulty.How to delay the progress of OA has become the most important problem.As a key regulator to maintain cartilage homeostasis,miR-146a has a regulatory effect on cartilage degeneration and inflammation.Toll-like receptor 4(TLR4)/Nuclear Factor-κB(NF-κB)signaling pathway maintains the metabolic homeostasis of cartilage by regulating immune and inflammatory responses.Although it has been studied that miR-146a mediates TLR4/NF-κB signaling pathway to delay OA,the specific mechanism is still not perfectly understood.This study reviews the effects of miR-146a on inflammatory factors,chondrocyte apoptosis,and cartilage extracellular matrix degradation through TLR4/NF-κB signaling pathway,so as to provide theoretical basis and potential molecular targets for the treatment of OA.