文献类型：期刊文献

英文题名：Research progress on high-altitude hypoxia pulmonary injury: pathogenesis and Chinese herbal medicine for prevention and treatment

作者：Song, Jiale[1,2];Zhang, Xiaojing[1];Mu, Hongfang[3];Zheng, Fuyixuan[1];Li, Wenbin[2,3];Wang, Rong[1,2]

第一作者：Song, Jiale

通信作者：Wang, R[1];Wang, R[2]

机构：[1]940th Hosp Joint Logist Support Force Chinese Peop, Dept Clin Pharm, Lanzhou, Peoples R China;[2]Gansu Univ Tradit Chinese Med, Sch Pharm, Lanzhou, Peoples R China;[3]940th Hosp Joint Logist Support Force Chinese Peop, Dept Pharm, Lanzhou, Peoples R China

第一机构：940th Hosp Joint Logist Support Force Chinese Peop, Dept Clin Pharm, Lanzhou, Peoples R China

通信机构：[1]corresponding author), 940th Hosp Joint Logist Support Force Chinese Peop, Dept Clin Pharm, Lanzhou, Peoples R China;[2]corresponding author), Gansu Univ Tradit Chinese Med, Sch Pharm, Lanzhou, Peoples R China.|[10735]甘肃中医药大学;

年份：2026

卷号：17

外文期刊名：FRONTIERS IN PHARMACOLOGY

收录：;Scopus(收录号：2-s2.0-105042481636);WOS:【SCI-EXPANDED(收录号:WOS:001761507500001)】；

基金：The author(s) declared that financial support was received for this work and/or its publication. This work was financially supported by the Supported by the National Natural Science Foundation of China, Science and Technology Project of Gansu Province and Natural Science Foundation of Gansu Province. (grant No. 82173738; No.23ZDFA0135; 23JRRA1667).

语种：英文

外文关键词：Chinese herbal medicine; high-altitude hypoxia; high-altitude pulmonary hypertension; high-altitude pulmonary oedema; pathogenesis; prevention and treatment

摘要：Tourism in high-altitude areas and high-altitude outdoor activities have seen a significant increase, and health threats centered around high-altitude pulmonary edema and high-altitude pulmonary hypertension have become increasingly prominent. Hypoxia, as the primary pathogenic trigger, initiates a cascade linking inflammatory responses, oxidative stress, and vascular dysfunction, culminating in a vicious cycle of injury. Leveraging its unique advantages of holistic regulation and multi-targeted synergistic effects, Chinese Herbal Medicines (CHM) shows promising potential in preventing and treating pulmonary injury associated with high-altitude hypoxia. Through single herbs or compound formulations, CHM targets the HIF-1 alpha pathway, scavenges reactive oxygen species, inhibits inflammatory cytokine release, protects the vascular endothelial barrier, and reverses abnormal vascular remodelling. This systematic review examines the core mechanisms by which high-altitude hypoxia causes acute and chronic pulmonary injury, and explores the action mechanisms of CHM in their prevention and treatment, aiming to provide a theoretical basis for the precise prevention and management of high-altitude hypoxia-related pulmonary diseases.