文献类型：期刊文献

中文题名：原发性失眠患者易损脑区的静息态功能磁共振成像研究:一项基于激活似然估计法的Meta分析

英文题名：Resting-state fMRI study of vulnerable brain regions in patients with primary insomnia:A Meta-analysis based on activation likelihood estimation

作者：张琴[1,2];侯勇哲[1];张伟[2];王琳[2]

第一作者：张琴

机构：[1]甘肃中医药大学第一临床医学院,兰州730000;[2]甘肃省中西医结合肿瘤临床医学研究中心甘肃中医药大学附属医院放射科,兰州730000

第一机构：甘肃中医药大学临床医学院

年份：2022

卷号：13

期号：6

起止页码：88

中文期刊名：磁共振成像

外文期刊名：Chinese Journal of Magnetic Resonance Imaging

收录：CSTPCD;;北大核心:【北大核心2020】；CSCD:【CSCD2021_2022】；

基金：甘肃省科技计划资助项目(编号:18JR2FA001);甘肃省教育厅重大项目(编号:LCCX2021001)。

语种：中文

中文关键词：静息态功能磁共振成像;原发性失眠;Meta分析;激活似然估计法;自发神经活动;易损脑区

外文关键词：resting state functional magnetic resonance imaging;primary insomnia;Meta analysis;activation likelihood estimation;spontaneous neural activity;impaired brain regions

摘要：目的探讨应用静息态功能磁共振成像(resting state functional magnetic resonance imaging,rs-fMRI)技术研究原发性失眠(primary insomnia,PI)患者较为一致的易损脑区,从而揭示PI脑损伤可能的神经机制。材料与方法检索2022年4月7日之前采用局部一致性(regional honogeneity,ReHo)及低频振幅/比率低频振幅/动态低频振幅(amplitude of low-frequency fluctuation/fraction amplitude of low-frequency fluctuation/dynamic amplitude of low-frequency fluctuation,ALFF/fALFF/dALFF)分析方法探讨PI患者脑功能改变的文献,按照严格的纳排标准,采用激活似然估计法(activation likelihood estimation,ALE)对既往研究中PI患者相对于健康对照组(healthy controls,HCs)自发神经活动异常的脑区进行整合分析。结果共纳入19篇文献20个研究(PI 706例,HCs 681例)。结合ReHo及ALFF/fALFF/dALFF数据元分析结果显示,PI患者相对于HCs左侧梭状回和海马旁回活动增加(体素分别为3640、928 mm3,P<0.05),并未发现活动减低的脑区。单独ALFF数据元分析结果显示,PI患者相对于HCs左侧梭状回活动增加(体素为1360 mm3,P<0.05),并未发现活动减低的脑区。单独ReHo数据元分析结果显示,PI患者相对于HCs并未出现任何活动增高或减低的脑区。结论本文通过ALE元分析发现PI患者较为一致的易损脑区为左侧梭状回和海马旁回,这有助于进一步从神经病理学的角度理解PI脑损伤。
Objective:To examine the use of resting state functional magnetic resonance imaging(rs-f MRI)technology in the study of the more consistent impaired brain regions in patients with primary insomnia(PI),in order to uncover the potential neural mechanism of PI brain injury.Materials and Methods:Before April 72022,the literature on changes in brain function in patients with PI was searched using regional honogeneity(ReHo)and amplitude of low-frequency fluctuation/fraction amplitude of low-frequency fluctuation/dynamic amplitude of low-frequency fluctuation(ALFF/fALFF/dALFF)analytic methods.The activation likelihood estimation(ALE)method was utilized to integrate and assess brain regions with aberrant spontaneous neural activity in patients with PI compared to healthy controls(HCs),based on tight exclusion criteria.Results:A total of 19 literatures and 20 studies(706 instances of PI and 681 cases of HCs)were included in the results.Combining ReHo and ALFF/fALFF/dALFF data element analysis,the results revealed that the activity of the left fusiform gyrus and parahippocampal gyrus in PI patients was higher than in HCs(voxels were 3640 and 928 mm3,respectively,P<0.05),and no brain region had lower activity.The results of ALFF data element analysis alone revealed that the activity of the left fusiform gyrus in PI patients was higher than in HCs(voxel was 1360 mm3,P<0.05),and no brain region had lower activity.The results of ReHo data element analysis alone revealed areas of the brain where PI patients do not exhibit any increased or decreased brain regions relative to HCs.Conclusions:In this paper,an ALE meta-analysis discovered that the more consistent susceptible brain regions in PI patients were the left fusiform gyrus and parahippocampal gyrus,which is helpful in understanding PI brain injury from a neuropathological standpoint.